4 documents found, page 1 of 1
Fodinibius alkaliphilus sp. nov., a moderately halophilic and alkaliphilic bact...
He, Yang; Simões, Marta Filipa Jesus Freitas; de la Haba, Rafael R.; Santos-Pereira, Cátia; Pereira-Sousa, Joana; Gomes, Joana S.A novel moderately halophilic and alkaliphilic Gram-stain-negative, strictly aerobic, bacterial strain (N2T) was isolated from an inland saltern in central Portugal. The taxonomic position of this isolate was determined based on polyphasic taxonomic and phylogenomic analysis. Phylogenetic analysis based on 16S rRNA gene sequences indicated that isolate N2T belongs to the genus Fodinibius, showing the highest si...
Neurodifferentiation and neuroprotection potential of mesenchymal stromal cell-...
Marques, Cláudia Raquel; Fuzeta, Miguel de Almeida; Cunha, Raquel Medina dos Santos; Pereira-Sousa, Joana; Silva, Deolinda; Campos, Jonas OliveiraParkinson’s disease (PD) is the second most common neurodegenerative disorder and is characterized by the degeneration of the dopamine (DA) neurons in the substantia nigra pars compacta, leading to a loss of DA in the basal ganglia. The presence of aggregates of alpha-synuclein (α-synuclein) is seen as the main contributor to the pathogenesis and progression of PD. Evidence suggests that the secretome of mesenc...
Learning the biochemical basis of axonal guidance: using Caenorhabditis elegans...
Castro, Andreia Cristiana Teixeira; Sousa, João Carlos; Vieira, Cármen Maria Leal; Pereira-Sousa, Joana; Vilasboas-Campos, Daniela; Marques, FernandaAim: Experimental models are a powerful aid in visualizing molecular phenomena. This work reports how the worm <i>Caenorhabditis elegans</i> (<i>C. elegans</i>) can be effectively explored for students to learn how molecular cues dramatically condition axonal guidance and define nervous system structure and behavior at the organism level. Summary of work: A loosely oriented observational activity preceded detai...
Aripiprazole offsets mutant ATXN3-induced motor dysfunction by targeting dopami...
Jalles, Ana; Vieira, Cármen Maria Leal; Pereira-Sousa, Joana; Campos, Daniela Vilasboas; Mota, Ana Francisca; Vasconcelos, SaraThe atypical antipsychotic aripiprazole is a Food and Drug Administration-approved drug for the treatment of psychotic, mood, and other psychiatric disorders. Previous drug discovery efforts pinpointed aripiprazole as an effective suppressor of Machado–Joseph disease (MJD) pathogenesis, as its administration resulted in a reduced abundance and aggregation of mutant Ataxin-3 (ATXN3) proteins. Dopamine partial ag...