7 documents found, page 1 of 1
Endocan as a marker of endotheliitis in COVID-19 patients: modulation by veno-v...
Reina-Couto, M; Alves, D; Silva-Pereira, C; Pereira-Terra, P; Martins, S; Bessa, J; Teixeira-Santos, L; Pinho, D; Morato, M; Dias, CC; Sarmento, A"Background and aims: Endocan has been scarcely explored in COVID-19, especially regarding its modulation by veno-venous extracorporeal membrane oxygenation (VV-ECMO), hypertension or previous renin-angiotensin-aldosterone system (RAAS) inhibitors treatment. We compared endocan and other endotheliitis markers in hospitalized COVID-19 patients and assessed their modulation by VV-ECMO, hypertension and previous R...
Evaluation of urinary cysteinyl leukotrienes as biomarkers of severity and puta...
Reina-Couto, M; Roboredo-Madeira, M; Pereira-Terra, P; Silva-Pereira, C; Martins, S; Teixeira-Santos, L; Pinho, D; Dias, A; Cordeiro, G; Dias, CCBackground Cysteinyl leukotrienes (CysLT) are potent inflammation-promoting mediators, but remain scarcely explored in COVID-19. We evaluated urinary CysLT (U-CysLT) relationship with disease severity and their usefulness for prognostication in hospitalized COVID-19 patients. The impact on U-CysLT of veno-venous extracorporeal membrane oxygenation (VV-ECMO) and of comorbidities such as hypertension and obesity ...
Proinflammatory and endothelial activation profiles in hospitalized COVID-19 pa...
Silva-Pereira, PDC; Reina-Couto, M; Alves, D; Pereira-Terra, P; Martins, S; Bessa, J; Teixeira-Santos, L; Pinho, D; Morato, M; Sarmento, A; Tavares, Mn/a
Urinary Cysteinyl Leukotrienes as Biomarkers of Endothelial Activation, Inflamm...
Reina-Couto, M; Santos-Oliveira, M; Pereira-Terra, P; Silva-Pereira, C; Quelhas-Santos, J; Duarte, Á; Martins, S; Serrão, P; Dias, CC; Morato, MCysteinyl leukotrienes (CysLT) are potent vascular leakage-promoting agents but have been scarcely explored in human septic shock (SS). We evaluated CysLT at admission and during hospitalization and their correlation with endothelial dysfunction, inflammation, oxidative stress, the renin–angiotensin–aldosterone system, and cardiac, renal, respiratory, and hepatic parameters in SS patients. Blood and spot-urine ...
Synthesis of a small library of nature-inspired xanthones and study of their an...
Resende, DISP; Pereira-Terra, P; Moreira, J; Freitas-Silva, J; Lemos, A; Gales, L; Pinto, E; Sousa, ME; Costa, PM; Pinto, MMMA series of thirteen xanthones 3-15 was prepared based on substitutional (appendage) diversity reactions. The series was structurally characterized based on their spectral data and HRMS, and the structures of xanthone derivatives 1, 7, and 8 were determined by single-crystal X-ray diffraction. This series, along with an in-house series of aminated xanthones 16-33, was tested for in-vitro antimicrobial activity ...
Unique Tracheal Fluid MicroRNA Signature Predicts Response to FETO in Patients ...
Pereira-Terra, P; Deprest, JA; Kholdebarin, R; Khoshgoo, N; DeKoninck, P; Boerema-De Munck, AA; Wang, J; Zhu, F; Rottier, RJ; Iwasiow, BMOBJECTIVE AND BACKGROUND:: Our objective was to determine the fetal in vivo microRNA signature in hypoplastic lungs of human fetuses with severe isolated congenital diaphragmatic hernia (CDH) and changes in tracheal and amniotic fluid of fetuses undergoing fetoscopic endoluminal tracheal occlusion (FETO) to reverse severe lung hypoplasia due to CDH. METHODS:: We profiled microRNA expression in prenatal human lu...
Neuroendocrine factors regulate retinoic acid receptors in normal and hypoplast...
Pereira-Terra, P; Moura, RS; Nogueira-Silva, C; Correia-Pinto, JRetinoic acid (RA) and ghrelin levels are altered in human hypoplastic lungs when compared to healthy lungs. Although considerable data have been obtained about RA, ghrelin and bombesin in the congenital diaphragmatic hernia (CDH) rat model, neuroendocrine factors have never been associated with the RA signalling pathway in this animal model. In this study, the interaction between neuroendocrine factors and RA ...