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Seroprevalence of Protective Antibodies Against Influenza and the Reduction of ...

Guiomar, R; Pereira da Silva, S; Costa, I; Conde, P; Cristóvão, P; Rodrigues, AP; Fernandes, A; Dias, AP; Couto, AR; Ramos, A; Moita, C; Rodrigues, C

Background: Seroepidemiological studies provide estimates of population-level immunity, prevalence/incidence of infections, and evaluation of vaccination programs. We assessed the seroprevalence of protective antibodies against influenza and evaluated the correlation of seroprevalence with the cumulative annual influenza incidence rate. Methods: We conducted an annual repeated cross-sectional seroepidemiologica...


Implementing an Influenza Vaccine Effectiveness Study in a Hospital Context in ...

Machado, A; Gomez, V; Panarra, A; Poças, J; Corte-Real, R; Peres, MJ; Nunes, B

Introduction: The project ‘Integrated Monitoring of Vaccines in Europe’ aimed to measure seasonal influenza vaccine effectiveness against hospitalised adults, aged 65 years and over, with influenza. We describe the protocol implementation in Portugal. Material and Methods: We implemented a test-negative design, targeting community-dwelling patients aged 65 years old and over hospitalised with severe acute respi...


Cross-Protection to New Drifted Influenza A(H3) Viruses and Prevalence of Prote...

Guiomar, R; Pereira da Silva, S; Conde, P; Cristóvão, P; Maia, AC; Pechirra, P; Rodrigues, AP; Nunes, B; Milho, L; Coelho, AP; Fernandes, A; Caseiro, P

INTRODUCTION: Immune profile for influenza viruses is highly changeable over time. Serological studies can assess the prevalence of influenza, estimate the risk of infection, highlight asymptomatic infection rate and can also provide data on vaccine coverage. The aims of the study were to evaluate pre-existing cross-protection against influenza A(H3) drift viruses and to assess influenza immunity in the Portugu...


Rastreio Neonatal de Hemoglobinopatias numa População Residente em Portugal

Peres, MJ; Carreiro, MH; Machado, MC; Seixas, T; Picanço, I; Batalha, L; Lavinha, J; Martins, MC

The primary objective of newborn screening of hemoglobinopathies is the early identification of infants with sickle cell disease, as they are at increased clinical risk. Other goals include the identification of other types of clinically significant hemoglobinopathies and the detection of heterozygous carriers followed by the screening and counselling of family members. We performed a pilot study for the neonat...


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