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Upregulation of inflammatory genes and downregulation of sclerostin gene expres...

Caetano-Lopes, J; Lopes, A; Rodrigues, A; Fernandes, D; Perpétuo, IP; Monjardino, T; Lucas, R; Monteiro, J; Konttinen, YT; Canhão, H; Fonseca, JE

Background: Fracture healing is orchestrated by a specific set of events that culminates in the repair of bone and reachievement of its biomechanical properties. The aim of our work was to study the sequence of gene expression events involved in inflammation and bone remodeling occurring in the early phases of callus formation in osteoporotic patients. Methodology/Principal Findings: Fifty-six patients submitte...


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