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Neurofilament proteins in neurodegenerative diseases
Liu, Q.; Xie, F.; Siedlak, S. L.; Nunomura, A.; Honda, K.; Moreira, P. I.; Zhua, X.; Smith, M. A.; Perry, G.The function of neurofilaments, the major component in large myelinated neurons, is not well understood even though they were discovered as structures over 100 years ago. Recent studies have suggested that neuro-filaments are closely related to many neurodegenerative diseases, such as amyotrophic lateral sclerosis, Parkinson disease Alzheimer disease, and diabetes. Using in vitro assays, cultures and transgenic...
Date: 2004
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Origin: Estudo Geral - Universidade de Coimbra