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Minocycline reduces mechanical allodynia and depressive-like behaviour in type-...
Amorim, Diana Alexandra Silva; Puga, Sónia Andreia Silva; Bragança, Rui Pedro Rebelo; Braga, António José Falcão Peres; Pertovaara, AnttiA common and devastating complication of diabetes mellitus is painful diabetic neuropathy (PDN) that can be accompanied by emotional disorders such as depression. A few studies have suggested that minocycline that inhibits microglia may attenuate pain hypersensitivity in PDN. Moreover, a recent study reported that minocycline has an acute antidepressive-like effect in diabetic animals. Here we studied whether (...
The medullary dorsal reticular nucleus as a relay for descending pronociception...
Pereira, Ana Carla David; Sagalajev, Boriss; Wei, Hong; Almeida, Armando; Pertovaara, Antti; Pinto-Ribeiro, FilipaMetabotropic glutamate receptor 5 (mGluR5) activation in the infralimbic cortex (IL) induces pronociceptive behavior in healthy and monoarthritic rats. Here we studied whether the medullary dorsal reticular nucleus (DRt) and the spinal TRPV1 are mediating the IL/mGluR5-induced spinal pronociception and whether the facilitation of pain behavior is correlated with changes in spinal dorsal horn neuron activity. Fo...
Galanin-mediated behavioural hyperalgesia from the dorsomedial nucleus of the h...
Amorim, Diana; Viisanen, Hanna; Wei, Hong; Almeida, Armando; Pertovaara, Antti; Pinto-Ribeiro, FilipaActivation of the dorsomedial nucleus of the hypothalamus (DMH) by galanin (GAL) induces behavioural hyperalgesia. Since DMH neurones do not project directly to the spinal cord, we hypothesized that the medullary dorsal reticular nucleus (DRt), a pronociceptive region projecting to the spinal dorsal horn (SDH) and/or the serotoninergic raphe-spinal pathway acting on the spinal 5-HT3 receptor (5HT3R) could relay...
A role of supraspinal galanin in behavioural hyperalgesia in the rat
Amorim, Diana; Pereira, Ana David; Marques, Patrícia; Puga, Sónia Andreia Silva; Rebelo, Patrícia; Costa, Patrício Soares; Pertovaara, AnttiData from the manuscript: "A role of supraspinal galanin in behavioural hyperalgesia in the rat" – by Amorim et al, PLoS One. Available at: http://hdl.handle.net/1822/30584; INTRODUCTION: In chronic pain disorders, galanin (GAL) is able to either facilitate or inhibit nociception in the spinal cord but the contribution of supraspinal galanin to pain signalling is mostly unknown. The dorsomedial nucleus of the h...
Amitriptyline reverses hyperalgesia and improves associated mood-like disorders...
Amorim, Diana; Pereira, Ana David; Pertovaara, Antti; Almeida, Armando; Ribeiro, Filipa PintoAffective disorders are common comorbidities of chronic inflammatory pain that are often overlooked in primary care. As the impact of inflammatory pain upon mood-like disorders in animal models is not well known, our objective was to assess whether prolonged experimental monoarthritis (ARTH) induced the development of anxiety and depressive-like behaviours in rodents and if amitriptyline, an antidepressant comm...
Data from the manuscript [A role of supraspinal galanin in behavioural hyperalg...
Amorim, Diana; David-Pereira, Ana; Marques, Patrícia; Puga, Sónia Andreia Silva; Rebelo, Patrícia; Costa, Patrício Soares; Pertovaara, AnttiManuscript: "A role of supraspinal galanin in behavioural hyperalgesia in the rat" – by Amorim et al, PLoS One. Available at: http://hdl.handle.net/1822/32480; In chronic pain disorders, galanin (GAL) is able to either facilitate or inhibit nociception in the spinal cord but the contribution of supraspinal galanin to pain signalling is mostly unknown. The dorsomedial nucleus of the hypothalamus (DMH) is rich in...
Pronociception from the dorsomedial nucleus of the hypothalamus is mediated by ...
Ribeiro, Filipa Pinto; Amorim, Diana; Pereira, Ana Carla David; Monteiro, Ana Maria; Costa, Patrício Soares; Pertovaara, Antti; Almeida, ArmandoThe dorsomedial nucleus of the hypothalamus (DMH) has been proposed to participate in stress-induced hyperalgesia through facilitation of pronociceptive cells in the rostroventromedial medulla (RVM). We hypothesized that the DMH participates in hyperalgesia induced by arthritis. The DMH was pharmacologically manipulated while assessing heat-evoked nociceptive behavior or the discharge rates of pronociceptive RV...
Dissociated modulation of conditioned place-preference and mechanical hypersens...
Wei, Hong; Viisanen, Hanna; Amorim, Diana; Koivisto, Ari; Pertovaara, AnttiUncorrected proof; Transient receptor potential ankyrin 1 (TRPA1) channel antagonists have suppressed mechanical hypersensitivity in peripheral neuropathy, while their effect on ongoing neuropathic pain is not yet known. Here, we assessed whether blocking the TRPA1 channel induces place-preference, an index for the relief of ongoing pain, in two experimental rat models of peripheral neuropathy. Diabetic neuropa...
Differential effects of left/right neuropathy on rats’ anxiety and cognitive be...
Leite-Almeida, Hugo; Cerqueira, João; Wei, Hong; Ribeiro, Nuno Costa; Martins, Helena Anjos; Sousa, Nuno; Pertovaara, Antti; Almeida, ArmandoChronic pain is frequently accompanied by a deterioration of emotional behavior and cognitive function. A small number of studies in humans concluded that pain-associated negative affect is more pronounced when pain is localized in the left side of the body. It has been suggested that such side bias results from cortical function lateralization. It is not known, however, if other pain-associated behavioral chan...
Response properties of nociceptive neurons in the caudal ventrolateral medulla ...
Ribeiro, Filipa Pinto; Ansah, Osei B.; Almeida, Armando; Pertovaara, AnttiWe characterized response properties of neurons in the caudal ventrolateral medulla (CVLM), a structure involved in pain modulation. Electrophysiological recordings were performed in pentobarbitoneanesthetized control and monoarthritic rats. Noxious pinch, heat, cold and colorectal distension were used for peripheral test stimulation. To study central modulation of CVLM neurons and role in mediating descending ...