6 documents found, page 1 of 1
Immunomodulatory inhibition of osteoclastogenesis by a marine microalgal ethano...
Carletti, Alessio; Pes, Katia; Tarasco, Marco; Rosa, Joana; Poudel, Sunil; Pereira, Hugo; Louro, Bruno; Cancela, M. Leonor; Laizé, VincentBackground: Targeting immune pathways to prevent bone loss represents a promising, yet underexplored therapeutic strategy. Methods: An ethanol-soluble fraction derived from the freeze-dried biomass of the marine microalga Skeletonema costatum (SKLT) was tested for its ability to modulate immune responses and inhibit osteoclastogenesis. Its effects were evaluated in a zebrafish model of bone regeneration, a meda...
Glyphosate: a terrestrial threat to marine plants? a study on the seagrass zost...
Deguette, Alizé; Pes, Katia; Vasconcellos, Bernard; Costa, Monya; Silva, João; Barrote, IsabelGlyphosate-based herbicides (GBHs) are extensively used worldwide, raising concerns about their potential effect on non-target aquatic ecosystems. This study investigated the short-term physiological effects of a commercially available GBH on the seagrass Zostera marina under controlled mesocosm conditions. Z. marina individuals were exposed to three concentrations of glyphosate (0.165, 51, and 5100 mg L−1 ) fo...
The osteogenic and mineralogenic potential of the microalgae Skeletonema costat...
Carletti, Alessio; Rosa, Joana; Pes, Katia; Borges, Inês; Santos, Tamara; Barreira, Luísa; Varela, João; Pereira, Hugo; Cancela, M. LeonorSkeletal disorders are problematic aspects for the aquaculture industry as skeletal deformities, which affect most species of farmed fish, increase production costs and affect fish welfare. Following recent findings that show the presence of osteoactive compounds in marine organisms, we evaluated the osteogenic and mineralogenic potential of commercially available microalgae strains Skeletonema costatum and Tet...
Short-term exposure to pharmaceuticals negatively impacts marine flatfish speci...
Pes, Katia; Ortiz-Delgado, Juan B.; Sarasquete, Carmen; Laizé, Vincent; Fernández, IgnacioThe marine habitat and its biodiversity can be impacted by released pharmaceuticals. The short-term (7 days) effect of 3 commonly used drugs - warfarin, dexamethasone and imidazole - on Senegalese sole (Solea senegalensis) juveniles was investigated. Occurrence of hemorrhages, histopathological alterations, antioxidant status, activity of antioxidant enzymes and expression of genes involved in the xenobiotic re...
Daily regulation of key metabolic pathways in two seagrasses under natural ligh...
Ruocco, Miriam; Barrote, Isabel; Hofman, Jan Dirk; Pes, Katia; Costa, Monya; Procaccini, Gabriele; Silva, João; Dattolo, EmanuelaThe circadian clock is an endogenous time-keeping mechanism that enables organisms to adapt to external environmental cycles. It produces rhythms of plant metabolism and physiology, and interacts with signaling pathways controlling daily and seasonal environmental responses through gene expression regulation. Downstream metabolic outputs, such as photosynthesis and sugar metabolism, besides being affected by th...
Biochemical and molecular responses of the Mediterranean mussel (Mytilus gallop...
Pes, Katia; Friese, Annika; Cox, Cymon J.; Laizé, Vincent; Fernández, IgnacioPharmaceuticals represent a group of emerging contaminants. The short-term effect (3 and 7 days) of warfarin (1 and 10 mg L-1), dexamethasone (0.392 and 3.92 mg L-1) and imidazole (0.013 and 0.13 mg L-1) exposure was evaluated on mussels (Mytilus galloprovincialis). Total antioxidant status, glutathione reductase, glutathione peroxidase (GPx) and superoxide dismutase enzyme activities, and the expression of gen...