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Assessing the impact of TiO2 nanomaterials on intestinal cells
Rolo, Dora; Pereira, Joana F.S.; Gonçalves, Lídia; Bettencourt, Ana; Jordan, Peter; Silva, Maria João; Matos, Paulo; Louro, HenriquetaUnderstanding the potential impact of nanomaterials (NMs) on human health requires further investigation into the organ-specific nano-bio interplay at the cellular and molecular levels. We showed increased chromosomal damage in intestinal cells exposed to some of in vitro digested Titanium dioxide (TiO2) NMs. The present study aimed to explore possible mechanisms linked to the uptake, epithelial barrier integri...
3D-printed biosurfactant-chitosan antibacterial coating for the prevention of s...
Narciso, Francisco; Cardoso, Sara; Monge, Nuno; Lourenço, Madalena; Martin, Victor; Duarte, Noélia; Santos, Catarina; Gomes, Pedro; Bettencourt, AnaFunding Information: The authors would like to thank the Portuguese government, Fundação para a Ciência e Tecnologia (FCT), for the financial support through national funds PTDC/BTM-SAL/29335/2017, under iMed.ULisboa UIDB/04138/2020 and UIDP/04138/2020 and under IPL IPL/2022/3DWounDres_ESELx. FCT is also acknowledged for the research initiation Grant BII/2/FF/2022. The authors acknowledge the financial support ...
Improving Chitosan Hydrogels Printability
Cardoso, Sara; Narciso, Francisco; Monge, Nuno; Bettencourt, Ana; Ribeiro, Isabel A. C.IPL IPL/2022/3DWounDres_ESELx. Publisher Copyright: © 2023 by the authors.; Chitosan is an interesting polymer to produce hydrogels suitable for the 3D printing of customized drug delivery systems. This study aimed at the achievement of chitosan-based scaffolds suitable for the incorporation of active components in the matrix or loaded into the pores. Several scaffolds were printed using different chitosan-base...
Bonding antimicrobial rhamnolipids onto medical grade PDMS
Dardouri, Maïssa; Aljnadi, Israa M.; Deuermeier, Jonas; Santos, Catarina; Costa, Fabiola; Martin, Victor; Fernandes, Maria H.; Gonçalves, LídiaFunding Information: Portugal 2020 for the Portuguese Mass Spectrometry Network (Rede Nacional de Espectrometria de Massa RNEM ) is also acknowledged. The authors also acknowledge the Designer Nuno Monge for the artwork, Isabel Dias Nogueira (Microlab, Instituto Superior Técnico, Lisbon University) for the technical assistance with the SEM analysis, Andreia Bento for the assistance with the UHPLC-MS equipment (...
Adverse Outcome Pathways Associated with the Ingestion of Titanium Dioxide Nano...
Rolo, Dora; Assunção, Ricardo; Ventura, Célia; Alvito, Paula; Gonçalves, Lídia; Martins, Carla; Bettencourt, Ana; Jordan, Peter; Vital, NádiaFunding Information: This research was funded by the Portuguese Foundation for Science and Technology FCT/MCTES through national funds (PIDDAC), PTDC/SAU-PUB/29481/2017 and co-funded by UIDB/00009/2020 (Centre for Toxicogenomics and Human Health—ToxOmics (UIDP/00009/2020; UIDB/00009/2020), iMed.ULisboa (UIDB/04138/2020+UIDP/04138/2020), CESAM (UIDP/50017/2020+UIDB/50017/2020+LA/P/0094/2020), and BioISI (UID/MUL...
Investigation of the genotoxicity of digested titanium dioxide nanomaterials in...
Vieira, Adriana; Vital, Nádia; Rolo, Dora; Roque, Rossana; Gonçalves, Lídia M.; Bettencourt, Ana; Silva, Maria João; Louro, HenriquetaFunding: This work was funded by national funds through the FCT - Foundation for Science and Technology, I.P., under the project PTDC/SAUPUB/29481/2017. Research co-funded by UIDB/00009/2020; UIDP/ 00009/2020 (Centre for Toxicogenomics and Human Health – ToxOmics, FCT- Foundation for Science and Technology). NV holds a FCT PhD Scholarship grant (2020.07168.BD). iMed.ULisboa (UIDB/04138/ 2020 and UIDP/04138/2020...
Analysis of the In Vitro Toxicity of Nanocelluloses in Human Lung Cells as Comp...
Pinto, Fátima; Lourenço, Ana Filipa; Pedrosa, Jorge F.S.; Gonçalves, Lídia; Ventura, Célia; Vital, Nádia; Bettencourt, Ana; Fernandes, Susete N.Funding Information: This research received funding from the Portuguese Foundation for Science and Technology (FCT/MCTES), through national funds (PIDDAC) under the project ToxApp4NanoCELFI (PTDC/SAUPUB/32587/2017). The following financial grants are also acknowledged: Projects UIDB/00009/2020 and UIDP/00009/2020 (ToxOmics); Projects UIDB/04138/2020 and UIDP/04138/2020 (iMed.Ulisboa) and L. Gonçalves Principal ...
Analysis of the characteristics and cytotoxicity of titanium dioxide nanomateri...
Bettencourt, Ana; Gonçalves, Lídia M.; Gramacho, Ana C.; Vieira, Adriana; Rolo, Dora; Martins, Carla; Assunção, Ricardo; Alvito, PaulaSeveral metallic nanomaterials (NMs), such as titanium dioxide nanomaterials (TiO2), present beneficial properties with a broad range of innovative applications. The human population is exposed to TiO2, particularly by ingestion, due to its increasing use as a food additive and inclusion in dietary supplements and food packaging materials. Whether this oral exposure may lead to adverse local or systemic outcome...