21 documents found, page 1 of 3

Atividade biológica de extratos orgânicos e aquosos de macroalgas marinhas do E...

The present study evaluated the biological activity of 12 marine macroalgae from Ceará State, Brazil. From the collected species 48 extracts (aqueous, dichloromethane, acetone and methanol extracts for each species) were obtained. The activity of extracts were rated at the following bioactivities: lethality in brine shrimp nauplii, inhibition of the development of sea urchin eggs, hemolytic activity on mice ery...

Atividade citotóxica e antimicrobiana de extratos hidrometanólicos de esponjas ...

Este estudo avaliou a atividade citotóxica e antimicrobiana dos extratos hidro-metanólicos das esponjas Amphimedon sp., Amphimedon viridis, Chondrilla aff. nucula, Echinodictyum dendroides, Halichondria sp., Placospongia intermedia, Tedania ignis e Tethya sp. coletadas no litoral cearense. A citotoxicidade foi avaliada quanto ao potencial hemolítico, à inibição do desenvolvimento de embriões de ouriço-do-mar e ...

In vitro citotoxicity of Pothomorphe peltata (L.) Miquel (Piperaceae), isolated...

Molecular biology of human epidermal receptors, signaling pathways and targeted...

Human epidermal receptors (HER1/2/3/4) belong to the class of receptor-type tyrosine kinases. After binding a ligand, dimerization, it will ocurr activation of intracellular kinases after two-dimensional and cytoplasmic tail reciprocal transphosphorylation. This transphosphorylation recruits signaling pathways such as Ras/Raf/MEK/Erk1-2, PI3-K/AKT and JAK/STAT, which can affect the cell cycle, cytoskeleton reor...

Synthesis of novel α-santonin derivatives as potential cytotoxic agents

Ten novel a -santonin derivatives have been synthesized as cytotoxic agents. The in vitro antitumor activity of these compounds has been evaluated against cancer cells lines. Structure-activity relationships indicate that a -methylene- g -lactone and endoperoxide functionalities play important roles in conferring cytotoxicity. The compounds 2e4, possessing the a -methylene- g -lactone group showed IC 50 values ...

Controlled release of Nor-β-lapachone by PLGA microparticles : a strategy for i...

Prostate cancer is one of the most common malignant tumors in males and it has become a major worldwide public health problem. This study characterizes the encapsulation of Nor-β-lapachone (NβL) in poly(d,l-lactide-co-glycolide) (PLGA) microcapsules and evaluates the cytotoxicity of the resulting drug-loaded system against metastatic prostate cancer cells. The microcapsules presented appropriate morphological f...

Biomedical properties and potentiality of Lippia microphylla Cham. and its esse...

Lippia microphylla Cham. (Verbanaceae) is an endemic underexploited Brazilian vegetal. This work reviewed the biological potentialities of Lippia microphylla, emphasizing the properties of essential oils (EOs) and analyzed scientific indicators about genus Lippia and L. microphylla. Databases from 1948 to the present were searched and a software (Vantage Point 7.1) associated with Derwent Innovation Index was u...

Counteracting effects on free radicals and histological alterations induced by ...

Casearia sylvestris Swartz is a medicinal plant widely distributed in Brazil. It has anti-inflammatory, antiulcer and antitumor activities and is popularly used to treat snakebites, wounds, diarrhea, flu and chest colds. Its leaves are rich in oxygenated tricyclic cis -clerodane diterpenes, particulary casearins. Herein, we evaluated the antioxidant activities of a fraction with casearins (FC) isolated from C. ...

Prospecção tecnológica do jaborandi (Pilocarpus microphyllus) : espécie economi...

The Pilocarpus microphyllus Stapf ex Wardlew spe cie is a native plant from north and northeast of Brazil occurring in eastern of Pará state, n orthwest and north of Maranhão and Piauí. It is one of the most important Brazilian medicinal species presents in pharmacopoeia of the entire world due to the use of its active pilocarpine. When using the Web of Science periodic base with Pilocarpus genus the result was...

Assessing chemical constituents of Mimosa caesalpiniifolia stem bark : possible...

Mimosa caesalpiniifolia is a native plant of the Brazilian northeast, and few studies have investigated its chemical composition and biological significance. This work describes the identification of the first chemical constituents in the ethanolic extract and fractions of M. caesalpiniifolia stem bark based on NMR, GC-qMS and HRMS analyses, as well as an assessment of their cytotoxic activity. GC-qMS analysis ...