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Assessment of the antibacterial, cytotoxic and antioxidant activities of Morus ...
Souza, G. R.; Oliveira-Junior, Raimundo Gonçalves de; Diniz, Tamara Coimbra; Branco, ALexsandro; Lima-Saraiva, Sara Raquel G.; Guimarães, A. L.his study was carried out to assess the antibacterial, cytotoxic and antioxidant activities of extracts of Morus nigra L. HPLC was used to determine the fingerprint chromatogram of the crude ethanolic extract (Mn-EtOH). The antibacterial effect was assessed through the method of microdilution. The cytotoxicity was tested against human tumour cell lines using the 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetr...
Suzuki-Miyaura coupling between 3-Iodolawsone and arylboronic acids. Synthesis ...
Gomes, Sara L. S.; Militão, Gardenia C. G.; Costa, Arinice M.; Pessoa, Cláudia Ó.; Costa-Lotufo, Letícia V.; Torres-Santos, Eduardo C.A series of 2-hydroxy-3-arylnaphthalene-1,4-diones (3-aryllawsones) were synthesized by Suzuki-Miyaura cross coupling reaction of 3-iodolawsone with arylboronic acids/esters. The hydroxylated resulting products were transformed into their corresponding N , N -diethyl carbamates. The antineoplastic and antileishmanial activities of the compounds were evaluated and compared with lapachol and its carbamate, provid...