6 documents found, page 1 of 1
Neuromodulation of acid-sensitive ion channels (ASICs) and anti-inflammatory po...
Liberato,Hortência Ribeiro; Maciel, Jéssica Bezerra; Silva, Antônio Wlisses Da; Bezerra, Maria Eduarda Uchoa; Brito, Luana San De OliveiraThe xanthone lichenxanthone did not show toxic effects (LC50>1.0 mg/mL). lichenxanthone prevented nociceptive behavior induced by acidic saline, and its analgesic effect was blocked by amiloride, highlighting the involvement of neuromodulation of acid-sensitive ion channels (ASICs). In the analysis of anti-inflammatory activity, concentrations of 0.1 and 0.5 mg/mL of lichenxanthone reduced the edema induced by ...
Biological properties of Oncocalyxone A: a review
Silva, Raí Emanuel da; Ribeiro , Fábio de Oliveira Silva; Araújo, Gisele Santos de; Iles, Bruno; Pessoa, Otília Deusdênia LoiolaQuinones are a classic example of molecules isolated from natural products. These compounds are secondary metabolites produced by plants, fungi, bacteria, and insects and correspond to an interesting chemical class ubiquitously found in nature. The [rel-8α-Hydroxy-5-hydroxymethyl-2-methoxy-8α, β-methyl-7, 8, 8a, 9-tetahydro-1, 4-anthracenedione] [oncocalyxone A, onco-A] is a benzoquinone of dark red color isola...
Biomedical properties and potentiality of Lippia microphylla Cham. and its esse...
Simões, Evelyne Rolim Braun; Santos, Evelyne Alves; Abreu, Maria Carolina de; Silva, Jurandy do Nascimento; Nunes, Nárcia Mariana FonsecaLippia microphylla Cham. (Verbanaceae) is an endemic underexploited Brazilian vegetal. This work reviewed the biological potentialities of Lippia microphylla, emphasizing the properties of essential oils (EOs) and analyzed scientific indicators about genus Lippia and L. microphylla. Databases from 1948 to the present were searched and a software (Vantage Point 7.1) associated with Derwent Innovation Index was u...
Chromomycin A2 induces autophagy in melanoma cells
Guimarães, Larissa Alves; Jimenez, Paula Christine; Sousa, Thiciana da Silva; Freitas, Hozana Patrícia S.; Rocha, Danilo Damasceno; Wilke, Diego VerasThe present study highlights the biological effects of chromomycin A2 toward metastatic melanoma cells in culture. Besides chromomycin A2, chromomycin A3 and demethylchromomycin A2 were also identified from the extract derived from Streptomyces sp., recovered from Paracuru Beach, located in the northeast region of Brazil. The cytotoxic activity of chromomycin A2 was evaluated across a panel of human tumor cell ...
Topical anti-inflammatory potential of Physalin E from Physalis angulata on exp...
Pinto, Natália Bitú; Morais, Talita Cavalcante; Carvalho, Karine Maria Martins Bezerra; Silva, Cecília Rocha; Andrade, Geanne Matos deThe anti-inflammatory effect of physalin E, a seco-steroid isolated from Physalis angulata L. was evaluated on acute and chronic models of dermatitis induced by 12-O-tetradecanoyl-phorbol-13- acetate (TPA) and oxazolone, respectively, in mouse ear. The changes in ear edema/thickness, production of pro-inflammatory cytokines (TNF- a and IFN- g ), myeloperoxidase (MPO) activity, and histological and immunohistoch...
Glicoalcaloides antifúngicos, flavonoides e outros constituintes químicos de So...
Pinto, Francisco das Chagas L.; Uchoa, Daniel Esdras de Andrade; Silveira, Edilberto Rocha; Pessoa, Otília Deusdênia Loiola; Braz-Filho, RaimundoTwo glycoalkaloids: solamargine and solasonine; three flavonoids: tiliroside, 7-O-α-L-ramnopyranosyl-kaempferol and 3-O-[ß-D-glucopyranosyl-(1→6)-α-L-ramnopyranosyl]-7- O-α-L-ramnopyranosyl-kaempferol, in addition to the tripeptide Leu-Ile-Val, the aminoacid proline and the eicosanoic acid were isolated from Solanum asperum (Solanaceae). The structures of all compounds were determined by interpretation of their...