3 documents found, page 1 of 1
Contribution to the knowledge of Iron Deficiency and Iron Overload through the ...
Pessoa, VeraO metabolismo do ferro centra-se no controlo rigoroso da absorção e manutenção do ferro. É através da disrupção da sua homeostasia que surgem doenças associadas à carência ou ao excesso de ferro. No caso da carência de ferro, pode desenvolver-se anemia microcítica e hipocrómica, enquanto uma absorção excessiva de ferro pode conduzir à hemocromatose, com consequente deposição de ferro em alguns tecidos e perda d...
Widening the Spectrum of TMPRSS6 Gene Pathogenic Variants Related with Heredita...
Pessoa, Vera; Oliveira, Alexandra; Santos, Daniela; Mendonça, Joana; Machado, Miguel P.; Ferrão, José; Vieira, Luís; Lopes, Pedro; Kislaya, IrinaIron-Refractory Iron-Deficiency Anemia (IRIDA) is a rare autosomal recessive hypochromic microcytic anemia derived from loss-of-function mutations in the TMPRSS6 gene, which encodes Matriptase-2, a negative regulator of hepcidin expression. IRIDA patients have high hepcidin levels that prevent iron absorption and recycling. Very few studies concerning this pathology have been carried out in the Portuguese popul...
Public health challenges in the XXI century
Miranda, Joana; Neto, Joana; Magalhães, João; Pessoa, VeraPublic health, as an art and a practical science, focuses on population health and seeks to promote and protect health and prevent disease, through proactive and healthy behaviours. In a global context, health systems are dealing with major challenges and a reflection is due in order to develop risk minimization strategies. Some examples of these challenges are the shortage of resources, rising health expenses,...