14 documents found, page 1 of 2
Relationship between Electrochemical Parameters, Cytotoxicity Data against Canc...
Paiva,Yen G. de; Silva,Thaissa L.; Xavier,André F. A.; Cardoso,Mariana F. C.; Silva,Fernando C. da; Silva,Maria F. S.; Pinheiro,Daniel P.Electrochemical methods are powerful in the characterization and design of redox-modulating agents. We, herein, report the electrochemical investigation, in aprotic medium, of eleven synthetic 3-thio-substituted-nor-beta-lapachones, along with the determination of cytotoxic activity and correspondent selectivity index, against several cancer cell lines and one normal cell. Four of the quinones are novel compoun...
Synthesis and Evaluation of Cytotoxic Effects of Amino-ester Derivatives of Nat...
Victor,Mauricio M.; David,Jorge M.; Santos,Marcelo A. S. dos; Barreiros,André L. B. S.; Barreiros,Marizeth L.; Andrade,Fernanda S.; Carvalho,Adriana A.Natural α,β-amyrins were isolated from endemic Brazilian Esenbeckia grandiflora Mart., and eight synthetic derivatives were obtained by esterification reactions with bromo acetate, followed by amine treatment. The structures of the all compounds were confirmed by 1H and 13C nuclear magnetic resonance (NMR), Fourier transform infrared (FTIR) and high-resolution mass spectrometry (HRMS) data analysis. The derivat...
Cytotoxicity and Leishmanicidal Activity of Isoniazid-Derived Hydrazones and 2-...
Amim,Raquel S.; Firmino,Gisele S. S.; Rego,Ana C. P. D.; Nery,Adriane L.; Da-Silva,Silvia A. G.; Souza,Marcus V. N. de; Pessoa,ClaudiaThe isoniazid-derived hydrazones 2-pyridinecarbaldehyde- (HPCIH), 2-acetylpyridine- (HAPIH), 2-benzoylpyridine- (HBPIH), 2-pyridineformamide- (HPAmIH) and 2-pyrazineformamide- (HPzAmIH) isonicotinoyl hydrazones, as well as the pyrazinamide-derived thiosemicarbazones 2-pyrazineformamide- (HPzAm4DH), N(4)-methyl-2-pyrazineformamide- (HPzAm4M), N(4)-ethyl-2-pyrazineformamide- (HPzAm4E) and N(4)-phenyl-2-pyrazinefo...
A new approach for the synthesis of 3-substituted cytotoxic nor-β-lapachones
Cardoso,Mariana F. C.; Silva,Illana M. C. B. da; Santos Júnior,Helvécio M. dos; Rocha,David R.; Araújo,Ana Jérsia; Pessoa,Claudia; Moraes,Manoel O. deSeveral studies have demonstrated the cytotoxic potential of nor-β-lapachone derivative against cancer cells. Considering nor-β-lapachone as an important prototype, a set of new 3-substituted nor-β-lapachones was synthesized by a new synthetic route that involves the use of synthetic intermediate generated for coupling with several nucleophiles containing the carbohydrate and 2H-pyrazole substituent moieties. A...
Evaluating methods for the isolation of marine-derived fungal strains and produ...
Kossuga,Miriam H.; Romminger,Stelamar; Xavier,Camila; Milanetto,Marília C.; Valle,Milene Z. do; Pimenta,Eli F.; Morais,Raquel P.; Carvalho,Erica deIn the present investigation we evaluate methods for the isolation and growth of marine-derived fungal strains in artificial media for the production of secondary metabolites. Inoculation of marine macroorganisms fragments in Petri dishes proved to be the most convenient procedure for the isolation of the largest number of strains. Among the growth media used, 3% malt extract showed the best result for strains ...
Interpretation of the presence of IgM and IgG antibodies in a rapid test for de...
Lima,José Rubens Costa; Rouquayrol,Maria Zélia; Callado,Maria Roseli Monteiro; Guedes,Maria Izabel Florindo; Pessoa,ClaudiaINTRODUCTION: The diagnosis of dengue and the differentiation between primary and secondary infections are important for monitoring the spread of the epidemic and identifying the risk of severe forms of the disease. The detection of immunoglobulin (Ig)M and IgG antibodies is the main technique for the laboratory diagnosis of dengue. The present study assessed the application of a rapid test for dengue concernin...
Folk uses and pharmacological properties of Casearia sylvestris: a medicinal re...
Ferreira,Paulo Michel P.; Costa-Lotufo,Leticia V.; Moraes,Manoel O.; Barros,Francisco W.A.; Martins,Aline M.A.; Cavalheiro,Alberto J.Folk uses and scientific investigations have highlighted the importance of Casearia sylvestris extracts and their relevant bioactive potential. The aim of this work was to review the pharmacological properties of C. sylvestris, emphasizing its anti-ulcer, anti-inflammatory, anti-ophidian and antitumor potentialities. Ethanolic extracts and essential oil of their leaves have antiulcerogenic activity and reduce g...
Novel 2-(R-phenyl)amino-3-(2-methylpropenyl)-[1,4]-naphthoquinones: synthesis, ...
Casellato,Annelise; Neves,Amanda P.; Carneiro,J. Walkimar de M.; Vargas,Maria D.; Visentin,Lorenzo do C.; Magalhães,Alviclér; Câmara,Celso A.Novel 2-(R-phenyl)amino-3-(2-methyl-propenyl)-[1,4]-naphthoquinones (R = H, 4-OMe, 4-Ferrocenyl, 4-Me, 3-Me, 4-I, 3-I, 4-CN, 3-CN, 4-NO2 and 3-NO2) derived from nor-lapachol [2-hydroxy-3-(2-methylpropenyl)-1,4-naphthoquinone] were obtained in good yields. Their structures were proposed on the basis of a single crystal X-ray diffraction study (R = OMe, 2b), ¹H and 13C NMR studies and calculations using the B3LYP...
Theoretical studies of the tautomerism in 3-(2-R-Phenylhydrazono)-naphthalene- ...
Francisco,Acácio I.; Vargas,Maria D.; Fragoso,Thaís P.; Carneiro,J. Walkimar de M.; Casellato,Annelise; Silva,Fernando de C. da; Ferreira,Vitor F.DFT calculations using the B3LYP and PBE1PBE functionals with the standard 6-31G(d) and 6-311+G(2d,p) basis sets were carried out for the 3-(2-phenylhydrazone)-naphthalene-1,2,4-trione system in solution (dmso) and in the gas phase, and showed the keto-hydrazone forms (rotamers Ia and Ib) to be more stable than the enol-azo forms (rotamers IIa and IIb, by about 14 kcal mol-1) and III (by approximately 6 kcal mo...
Cytotoxic, trypanocidal activities and physicochemical parameters of nor-²-lapa...
Silva Júnior,Eufrânio N. da; Moura,Maria Aline B. F. de; Pinto,Antonio V.; Pinto,Maria do Carmo F. R.; Souza,Maria Cecília B. V. de; Araújo,Ana J.The cytotoxicities of five nor-²-lapachone-based 1,2,3-triazoles and the precursor azidonaphthoquinone were assayed against six neoplasic cancer cell lines: SF-295 (central nervous system), HCT-8 (colon), MDAMB-435 (melanoma), HL-60 (leukaemia), PC-3 (prostate) and B-16 (murine melanoma). IC50 values ranging from 0.43 to 9.48 µM were obtained. 3-(4-(1-hydroxycyclohexyl)-1H-1,2,3-triazol-1yl)-2,2-dimethylnaphtho...