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Functional and structural evaluation of the antileukaemic enzyme l-asparaginase...
de Moura, Werner Alfinito Feio [UNESP]; Schultz, Leonardo [UNESP]; Breyer, Carlos Alexandre [UNESP]; de Oliveira, Ana Laura Pires [UNESP]Made available in DSpace on 2020-12-12T02:45:48Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-01-01; Acute lymphoblastic leukaemia (ALL) affects lymphoblastic cells and is the most common neoplasm during childhood. Among the pharmaceuticals used in the treatment protocols for ALL, Asparaginase (ASNase) from Escherichia coli (EcAII) is an essential biodrug. Meanwhile, the use of EcAII in neoplastic trea...
Effect of osmolytes on the activity of anti-cancer enzyme L-Asparaginase II fro...
Wlodarczyk, Samarina R.; Costa-Silva, Tales A.; Pessoa-Jr, Adalberto; Madeira, Pedro; Monteiro, GiseleL-asparaginase is used for the treatment of acute lymphoblastic leukaemia (ALL); however, its formulation presents drawbacks such as a lack of stability and formation of aggregates. Osmolytes are small molecules accumulated by cells in response to environmental stresses and present a protective behaviour, favouring the equilibrium of macromolecules towards the native conformation. Therefore, osmolytes are emplo...