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Cerebellar morphometric and spectroscopic biomarkers for Machado-Joseph Disease

Miranda, Catarina Oliveira; Nobre, Rui Jorge; Paiva, Vítor Hugo; Duarte, João Valente; Castelhano, João; Petrella, Lorena Itati; Sereno, José

Machado-Joseph disease (MJD) or Spinocerebellar ataxia type 3 (SCA3) is the most common form of dominant SCA worldwide. Magnetic Resonance Imaging (MRI) and Proton Magnetic Resonance Spectroscopy (1H-MRS) provide promising non-invasive diagnostic and follow-up tools, also serving to evaluate therapies efficacy. However, pre-clinical studies showing relationship between MRI-MRS based biomarkers and functional pe...

Date: 2022   |   Origin: Estudo Geral - Universidade de Coimbra
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