2 documents found, page 1 of 1
Plasma Lipocalin 2 in Alzheimer's disease: potential utility in the differentia...
Hermann, Peter; Villar-Piqué, Anna; Schmitz, Matthias; Schmidt, Christian; Varges, Daniela; Goebel, Stefan; Bunck, Timothy; Lindemann, HannaBackground: Lipocalin-2 is a glycoprotein that is involved in various physiological and pathophysiological processes. In the brain, it is expressed in response to vascular and other brain injury, as well as in Alzheimer’s disease in reactive microglia and astrocytes. Plasma Lipocalin-2 has been proposed as a biomarker for Alzheimer’s disease but available data is scarce and inconsistent. Thus, we evaluated plas...
Cerebrospinal fluid lipocalin 2 as a novel biomarker for the differential diagn...
Llorens, Franc; Hermann, Peter; Villar-Piqué, Anna; Diaz-Lucena, Daniela; Nägga, Katarina; Hansson, Oskar; Santana, Isabel; Schmitz, MatthiasThe clinical diagnosis of vascular dementia (VaD) is based on imaging criteria, and specific biochemical markers are not available. Here, we investigated the potential of cerebrospinal fluid (CSF) lipocalin 2 (LCN2), a secreted glycoprotein that has been suggested as mediating neuronal damage in vascular brain injuries. The study included four independent cohorts with a total n = 472 samples. LCN2 was significa...