4 documents found, page 1 of 1
Towards a consensus definition of allostatic load: a multi-cohort, multi-system...
McCrory, C; McLoughlin, S; Layte, R; NiCheallaigh, C; O'Halloran, AM; Barros, H; Berkman, LF; Bochud, M; Crimmins, EM; Farrell, MT; Fraga, S; Grundy, EBackground: Allostatic load (AL) is a multi-system composite index for quantifying physiological dysregulation caused by life course stressors. For over 30 years, an extensive body of research has drawn on the AL framework but has been hampered by the lack of a consistent definition.Methods: This study analyses data for 67,126 individuals aged 40-111 years participating in 13 different cohort studies and 40 bio...
Special Report: The Biology of Inequalities in Health: The Lifepath Consortium
Vineis, P; Avendano-Pabon, M; Barros, H; Bartley, M; Carmeli, C; Carra, L; Chadeau-Hyam, M; Costa, G; Delpierre, C; D'Errico, A; Fraga, S; Giles, GFunded by the European Commission Horizon 2020 programme, the Lifepath research consortium aimed to investigate the effects of socioeconomic inequalities on the biology of healthy aging. The main research questions included the impact of inequalities on health, the role of behavioral and other risk factors, the underlying biological mechanisms, the efficacy of selected policies, and the general implications of ...
Childhood socioeconomic conditions are associated with increased chronic low-gr...
Fraga, S; Severo, M; Ramos, E; Kelly-Irving, M; Silva, S; Ribeiro, AI; Petrovic, D; Barros, H; Stringhini, SObjective Early life adversity has been associated with increased risk of inflammation and inflammation-related diseases in adulthood. This study aimed to examine the association of childhood socioeconomic conditions with chronic low-grade inflammation over adolescence. Methods We used information on 2942 members (1507 girls and 1435 boys) of the EPITeen (Epidemiological Health Investigation of Teenagers in Por...
The contribution of sleep to social inequalities in cardiovascular disorders: a...
Petrovic, D; Haba-Rubio, J; de Mestral, Vargas, C; Kelly-Irving, M; Vineis, P; Kivimäki, M; Nyberg, S; Gandini, M; Bochud, M; Vollenweider, PAims: Sleep disturbances exhibit a strong social patterning, and inadequate sleep has been associated with adverse health outcomes, including cardiovascular disorders (CVD). However, the contribution of sleep to socioeconomic inequalities in CVD is unclear. This study pools data from eight European cohorts to investigate the role of sleep duration in the association between life-course socioeconomic status (SES...