18 documents found, page 1 of 2
Unravelling the dermatological potential of the brown seaweed Carpomitra costata
Susano, Patrícia; Silva, Joana; Alves, Celso; Martins, Alice; Gaspar, Helena; Pinteus, Susete; Mouga, Teresa; Goettert, Márcia Ines; Petrovski, ZeljkoThe ever-increasing interest in keeping a young appearance and healthy skin has leveraged the skincare industry. This, coupled together with the increased concern regarding the safety of synthetic products, has boosted the demand for new and safer natural ingredients. Accordingly, the aim of this study was to evaluate the dermatological potential of the brown seaweed Carpomitra costata. The antioxidant, anti-en...
Tailoring amphotericin B as an ionic liquid: an upfront strategy to potentiate ...
Hartmann, Diego O.; Shimizu, Karina; Rothkegel, Maika; Petkovic, Marija; Ferraz, Ricardo; Petrovski, Zeljko; Branco, Luís C.; Lopes, José N. CanongiaAspergillus species are the primary cause of invasive aspergillosis, which afflicts hundreds of thousands of patients yearly, with high mortality rates. Amphotericin B is considered the gold standard in antifungal drug therapy, due to its broad-spectrum activity and rarely reported resistance. However, low solubility and permeability, as well as considerable toxicity, challenge its administration. Lipid formula...
Marine environmental plastic pollution: mitigation by microorganism degradation...
Oliveira, Juliana; Belchior, Afonso; da Silva, Verónica D.; Rotter, Ana; Petrovski, Zeljko; Almeida, Pedro L.; Lourenço; Gaudencio, Susana P.Plastics are very useful materials and present numerous advantages in the daily life of individuals and society. However, plastics are accumulating in the environment and due to their low biodegradability rate, this problem will persist for centuries. Until recently, oceans were treated as places to dispose of litter, thus the persistent substances are causing serious pollution issues. Plastic and microplastic ...
Highlighting the biological potential of the brown seaweed Fucus spiralis for s...
Freitas, Rafaela; Martins, Alice; Silva, Joana; Alves, Celso; Pinteus, Susete; Alves, Joana; Teodoro, Fernando; Ribeiro, Helena MargaridaSkin aging is a biological process influenced by intrinsic and extrinsic factors. The last ones, mainly exposure to UV radiation, increases reactive oxygen species (ROS) production leading to a loss of extracellular matrix, also enhanced by enzymatic degradation of matrix supporting molecules. Thus, and with the growing demand for eco-friendly skin products, natural compounds extracted from brown seaweeds revea...
Antimicrobial activities of highly bioavailable organic salts and ionic liquids...
Santos, Miguel M.; Alves, Celso; Silva, Joana; Florindo, Catarina; Petrovski, Zeljko; Marrucho, Isabel M.; Pedrosa, Rui; Branco, Luís C.As the development of novel antibiotics has been at a halt for several decades, chemically enhancing existing drugs is a very promising approach to drug development. Herein, we report the preparation of twelve organic salts and ionic liquids (OSILs) from ciprofloxacin and norfloxacin as anions with enhanced antimicrobial activity. Each one of the fluoroquinolones (FQs) was combined with six di erent organic hyd...
Highlighting the Biological Potential of the Brown Seaweed Fucus spiralis for S...
Freitas, Rafaela; Martins, Alice; Silva, Joana; Alves, Celso; Pinteus, Susete; Alves, Joana; Teodoro, Fernando; Ribeiro, Helena MargaridaSkin aging is a biological process influenced by intrinsic and extrinsic factors. The last ones, mainly exposure to UV radiation, increases reactive oxygen species (ROS) production leading to a loss of extracellular matrix, also enhanced by enzymatic degradation of matrix supporting molecules. Thus, and with the growing demand for eco-friendly skin products, natural compounds extracted from brown seaweeds revea...
Tackling bacterial resistance using antibiotics as ionic liquids and organic salts
Santos, Miguel M.; Grilo, Inês R.; Ferraz, Ricardo; Madeira, Diogo A.; Soares, Bárbara M.; Inácio, Núria; Pinheiro, Luís; Petrovski, ZeljkoBacterial resistance to current antibiotics has a major impact on worldwide human health, leading to 700K deaths every year. The development of novel antibiotics did not present significant progress, namely regarding clinical trials, over the last years due to low returns. Thus, innovative alternatives must be devised to tackle the continuous rise of antimicrobial resistance. Ionic Liquids and Organic Salts fro...
Ionic Liquids Synthesis – Methodologies
Ferraz, Ricardo; Prudêncio, Cristina; Vieira, Mónica; Fernandes, Rúben; Noronha, João Paulo; Petrovski, ZeljkoIonic Liquids (IL) are salts with at least one organic cation. The term “Ionic Liquid” has been restricted to salts with melting point below 100° C [1]. In the recent years, (ILs) have gained popularity in science and technology. The large number of possible cation/ anion combinations allows a great variety of tunable interactions; also their unique properties and characteristics make it a promising and an attr...
Evaluation of solubility and partition properties of ampicillin-based ionic liq...
Florindo, Catarina; Araújo, João; Alves, Filipa; Matos, Carla; Ferraz, Ricardo; Prudêncio, Cristina; Noronha, João Paulo; Petrovski, ZeljkoIn order to overcome the problems associated with low water solubility, and consequently low bioavailability of active pharmaceutical ingredients (APIs), herein we explore a modular ionic liquid synthetic strategy for improved APIs. Ionic liquids containing l-ampicillin as active pharmaceutical ingredient anion were prepared using the methodology developed in our previous work, using organic cations selected fr...
Development and biological evaluation of API-ILs based on anti-bacterial and an...
Ferraz, Ricardo; Branco, Luís; Fernandes, Rúben; Prudêncio, Cristina; Noronha, João Paulo; Petrovski, ZeljkoIn recent years Ionic Liquids (ILs) are being applied in life sciences. ILs are being produce with active pharmaceutical drugs (API) as they can reduce polymorphism and drug solubility problems [1] Also ILs are being applied as a drug delivery device in innovative therapies What is appealing in ILs is the ILs building up platform, the counter-ion can be carefully chosen in order to avoid undesirable side effect...