4 documents found, page 1 of 1
Measuring progress and projecting attainment on the basis of past trends of the...
Fullman, Nancy; Barber, Ryan M; Abajobir, Amanuel Alemu; Abate, Kalkidan Hassen; Abbafati, Cristiana; Abbas, Kaja M; Abd-Allah, FoadBackground: The UN's Sustainable Development Goals (SDGs) are grounded in the global ambition of "leaving no one behind". Understanding today's gains and gaps for the health-related SDGs is essential for decision makers as they aim to improve the health of populations. As part of the Global Burden of Diseases, Injuries, and Risk Factors Study 2016 (GBD 2016), we measured 37 of the 50 health-related SDG indicato...
Temporal trends of molecular markers associated with artemether-lumefantrine to...
Malmberg, Maja; Ngasala, Billy; Ferreira, Pedro E.; Larsson, Erik; Jovel, Irina; Hjalmarsson, Angelica; Petzold, Max; Premji, Zul; Gil, José PedroBackground: Development and spread of Plasmodium falciparum resistance to artemisinin-based combination therapy (ACT) constitutes a major threat to recent global malaria control achievements. Surveillance of molecular markers could act as an early warning system of ACT-resistance before clinical treatment failures are apparent. The aim of this study was to analyse temporal trends of established genotypes associ...
Rapid diagnostic tests for molecular surveillance of Plasmodium falciparum mala...
Morris, Ulrika; Aydin-Schmidt, Berit; Shakely, Deler; Martensson, Andreas; Jornhagen, Louise; Ali, Abdullah S.; Msellem, Mwinyi I.; Petzold, MaxBackground: The need for new malaria surveillance tools and strategies is critical, given improved global malaria control and regional elimination efforts. High quality Plasmodium falciparum DNA can reliably be extracted from malaria rapid diagnostic tests (RDTs). Together with highly sensitive molecular assays, wide scale collection of used RDTs may serve as a modern tool for improved malaria case detection an...
Novel polymorphisms in plasmodium falciparum ABC transporter genes are associat...
Veiga, Maria Isabel; Pousão-Ferreira, Pedro; Jornhagen, Louise; Malmberg, Maja; Kone, Aminatou; Schmidt, Berit Aydin; Petzold, Max; Bjorkman, AndersChemotherapy is a critical component of malaria control. However, the most deadly malaria pathogen, Plasmodium falciparum, has repeatedly mounted resistance against a series of antimalarial drugs used in the last decades. Southeast Asia is an epicenter of emerging antimalarial drug resistance, including recent resistance to the artemisinins, the core component of all recommended antimalarial combination therapi...