Introduction: Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS+HIPEC) is a locoregional surgical therapy applied in patients with peritoneal-only metastatic disease of primary abdominal malignancies and is associated with increased overall survival. Our goal was to evaluate short-term outcomes after CRS+HIPEC regarding surgical morbidity, as well as to identify factors associated with s...
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Introduction: Evidence about the advantage of Lichtenstein’s repair, the guidelines’ recommended technique, is scarce regarding postoperative chronic inguinal pain (CPIP). The primary aim of this study was to compare CPIP in patients undergoing Lichtenstein versus other techniques. Methods: Prospective multicentric cohort study including consecutive adults undergoing elective inguinal hernia repair in Portugues...
Introduction: Breast cancer biological subtype has an important impact in the definition of the treatment strategy and the prognosis. However, the influence of neoadjuvant chemotherapy in the immunohistochemistry profile of the tumor is not well clarified. This study aims to evaluate the incidence of immunohistochemistry profile changes after neoadjuvant chemotherapy and the impact of these changes in adj...
Introduction: Evidence about the advantage of Lichtenstein’s repair, the guidelines’ recommended technique, is scarce regarding postoperative chronic inguinal pain (CPIP). The primary aim of this study was to compare CPIP in patients undergoing Lichtenstein versus other techniques. Methods: Prospective multicentric cohort study including consecutive adults undergoing elective inguinal hernia repair in Portugues...
Objectives: Within the framework of the burden of disease (BoD) approach, disease, and injury burden estimates attributable to risk factors are a useful guide for policy formulation and priority setting in disease prevention. Considering the important differences in methods, and their impact on burden estimates, we conducted a scoping literature review to: (1) map the BoD assessments including risk factors perf...
This systematic literature review aimed to provide an overview of the characteristics and methods used in studies applying the Disability-Adjusted Life Years (DALY) concept for infectious diseases within European Union (EU)/European Economic Area (EEA)/European Free Trade Association (EFTA) countries and the United Kingdom. Electronic databases and grey literature were searched for articles reporting the assess...
Introduction: The impact of kirsten rat sarcoma viral oncogene homolog (KRAS) mutational status on surgery planning for colorectal liver metastases (CRLM) remains unknown. The aim of the study was to evaluate the impact of type of liver surgery and margin status in recurrence free survival (RFS) of patients with CRLM, according to KRAS mutational status. Materials and methods: Retrospective review of all patien...