4 documents found, page 1 of 1
Global age-sex-specific mortality, life expectancy, and population estimates in...
Schumacher, AE; Kyu, HH; Aali, A; Abbafati, C; Abbas, J; Abbasgholizadeh, R; Abbasi, MA; Abbasian, M; Abd ElHafeez, S; Abdelmasseh, M; Abd Elsalam, SBackground: Estimates of demographic metrics are crucial to assess levels and trends of population health outcomes. The profound impact of the COVID-19 pandemic on populations worldwide has underscored the need for timely estimates to understand this unprecedented event within the context of long-term population health trends. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021 provides n...
Liposomal cytarabine as cancer therapy: From chemistry to medicine
Salehi, B; Selamoglu, Z; Mileski, KS; Pezzani, R; Redaelli, M; Cho, WC; Kobarfard, F; Rajabi, S; Martorell, M; Kumar, P; Martins, N; Santra, TSCancer is the second leading cause of death worldwide. The main modality to fight against cancer is surgery, radiotherapy, and chemotherapy, and more recently targeted therapy, gene therapy and immunotherapy, which play important roles in treating cancer patients. In the last decades, chemotherapy has been well developed. Nonetheless, administration of the drug is not always successful, as limited drug dosage c...
Synergistic effects of plant derivatives and conventional chemotherapeutic agen...
Pezzani, R; Salehi, B; Vitalini, S; Iriti, M; Zuñiga, FA; Sharifi-Rad, J; Martorell, M; Martins, NSynergy is a process in which some substances cooperate to reach a combined effect that is greater than the sum of their separate effects. It can be considered a natural “straight” strategy which has evolved by nature to obtain more efficacy at low cost. In this regard, synergistic effects may be observed in the interaction between herbal products and conventional drugs or biochemical compounds. It is important...
The therapeutic potential of naringenin: A review of clinical trials
Salehi, B; Fokou, P; Sharifi-Rad, M; Zucca, P; Pezzani, R; Martins, N; Sharifi-Rad, JNaringenin is a flavonoid belonging to flavanones subclass. It is widely distributed in several Citrus fruits, bergamot, tomatoes and other fruits, being also found in its glycosides form (mainly naringin). Several biological activities have been ascribed to this phytochemical, among them antioxidant, antitumor, antiviral, antibacterial, anti-inflammatory, antiadipogenic and cardioprotective effects. Nonetheles...