3 documents found, page 1 of 1
Enhanced anticancer activity of Hymenocardia acida stem bark extract loaded int...
Adedokun, Oluwasegun; Ntungwe, Epole N.; Viegas, Cláudia; Adesina Ayinde, Bunyamin; Barboni, Luciano; Maggi, Filippo; Saraiva, Lucilia; Rijo, PatríciaHymenocardia acida (H. acida) is an African well-known shrub recognized for numerous medicinal properties, including its cancer management potential. The advent of nanotechnology in delivering bioactive medicinal plant extract with poor solubility has improved the drug delivery system, for a better therapeutic value of several drugs from natural origins. This study aimed to evaluate the anticancer properties of...
Naphthoylhydrazones: coordination to metal ions and biological screening
Ribeiro, Nadia; Galvao, Adelino M.; Gomes, Clara S. B.; Ramos, Helena; Pinheiro, Rute; Saraiva, Lucilia; Ntungwe, Epole; Isca, Vera; Rijo, PatriciaWe report the synthesis of 3-hydroxyl-2-naphthoylhydrazones containing pyrrole (HL1), furane (HL2) and thiophene (HL3) moieties and their V(IV)O-, Cu(II)- and Zn(II)-complexes. All compounds are characterized by the usual analytical techniques and coordination of the ligands to the metal ions is discussed based on spectroscopic data (FTIR, UV-vis, EPR and NMR) as well as CAMB3LYP DFT/TDDFT calculations, indicat...
VINYL SULFONES AS CASPASE INHIBITORS
Santos, Maria M. M.; Newton, Ana S.; Coutinho, Isabel; Gloria, Paulo M. C.; Saraiva, Lucilia; Moreira, Rui