4 documents found, page 1 of 1
Absolute Configuration Reassignment of Natural Products: An Overview of the Las...
Batista,Andrea N. L.; Angrisani,Bianca R. P.; Lima,Maria Emanuelle D.; Silva,Stephanie M. P. Da; Schettini,Vitória H.; Chagas,Higor A.The assignment of absolute configuration (AC) is a crucial step in the structural characterization of natural products, especially for those subjected to biological assays. Methods such as X-ray crystallography, stereocontrolled organic synthesis, nuclear magnetic resonance (NMR), and chiroptical spectroscopies are commonly used to determine the AC of chiral natural compounds. Even with these well-established t...
Absolute Configuration of (−)-Cubebin, a Classical Lignan with Pharmacological ...
Macedo,Arthur L.; Martorano,Lucas H.; Albuquerque,Ana Carolina F. de; Fiorot,Rodolfo G.; Carneiro,José W. M.; Campos,Vinicius R.This work describes the first determination of the absolute configuration (AC) of (−)-cubebin by means of electronic circular dichroism (ECD), supported by quantum chemical calculations. The comparison of experimental ECD with the corresponding quantum chemical prediction for the proper diastereoisomer resulted in the definitive assignment of the AC of the naturally occurring (−)-cubebin as (8R,8aR,9S). The cha...
Perezone, from the gorgonian Pseudopterogorgia rigida, induces oxidative stress...
Abreu,Paula A.; Wilke,Diego V.; Araujo,Ana J.; Marinho-Filho,José Delano B.; Ferreira,Elthon G.; Ribeiro,Carlos Margo R.; Pinheiro,Leandro S.Abstract Four bisabolanes 1–4, including perezone (1) and triacetyl perezone (2), were isolated through a bioassay-guided fractionation of the extract obtained from the Caribbean gorgonian coral Pseudopterogorgia rigida collected during an expedition cruise to the Bahamas. All isolated compounds showed to be cytotoxic toward panel of four human tumor cell lines, as quantified by the MTT assay after 72 h incubat...
Atividade moluscicida de plantas: uma alternativa profilática
Cantanhede,Selma Patrícia D.; Marques,Adriana de M.; Silva-Souza,Nêuton; Valverde,Alessandra L.Uma das formas de combate a helmintos que possuem moluscos em seu ciclo biológico é o controle da população malacológica. A tentativa de combater os criadouros naturais de hospedeiros intermediários, através de moluscicidas, tem sido uma das formas almejadas para a redução da incidência de enfermidades, como as esquistossomoses e fascioloses. Essa medida epidemiológica tem se concretizado através da utilização ...