13 documents found, page 1 of 2

Localização subcelular do novo fotossensibilizador em células do melanoma ocula...

Introdução: O melanoma ocular é o objetivo de várias investigações em medicina e medicina veterinária devido à baixa taxa de resposta aos tratamentos conservadores convencionais1. A terapia fotodinâmica (PDT) é uma terapia mais conservadora para os tecidos não neoplásicos, que induz e ativa as vias de morte celular nos tecidos neoplásicos alvo2,3. O fotossensibilizador, luz e oxigenio são os três componentes vi...

IN VITRO PHOTODYNAMIC THERAPY ON OCULAR MELANOMA CELLS

Purpose. To evaluate the effect of newly developed Ring-fused chlorins on cell proliferation of ocular melanoma. Methods. Human cell line MP-41 and a canine primary culture were subjected to the photosensitizers at concentrations between 0,5-1000 nM for 24 hours. The cells were irradiated with 10J (ƛ>570nm). Control groups included: untreated cells and cells submitted only to the administration vehicle (dimethy...

Flow Chemistry: Sequential Flow Processes for the Synthesis of Heterocycles

Flow chemistry is changing the face of synthetic organic chemistry laboratories in both academia and industry. The application of continuous flow processes for multistep reactions is becoming a golden rule for the sustainable synthesis of heterocycles. In this chapter, several recent examples of the application of flow processes for the synthesis of relevant heterocycles, including active pharmaceutical ingredi...

Isolation and Identification of Cytotoxic Compounds Present in Biomaterial Life®

Direct pulp capping consists of a procedure in which a material is directly placed over the exposed pulp to maintain dental vitality. Although still widely used in clinical practice, previous in vitro studies found that the biomaterial Life® presented high cytotoxicity, leading to cell death. This study aimed to identify the Life® constituents responsible for its cytotoxic effects on odontoblast-like cells (MDP...

Sulfonated tryptanthrin anolyte increases performance in pH neutral aqueous red...

Aqueous organic redox flow batteries (AORFBs) hold great promise as low-cost, environmentally friendly and safe alternative energy storage media. Here we present aqueous organometallic and all-organic active materials for RFBs with a water-soluble active material, sulfonated tryptanthrin (TRYP-SO3H), working at a neutral pH and showing long-term stability. Electrochemical measurements show that TRYP-SO3H displa...

Mechanochemical in situ generated gas reactant for the solvent-free hydrogenati...

The synthesis of chlorins was performed by hydrogenation of porphyrins using diimide generated and consumed under mechanical activation. The reaction conditions achievable under ball milling, absence of solvent and use of hydrazine hydrate as diimide source, allowed the hydrogenation of porphyrins with high conversion, high selectivity, and nearly ideal sustainability scores (atom economy of 97% and E-factor of...

Modern Methods for the Sustainable Synthesis of Metalloporphyrins

Metalloporphyrins are involved in many and diverse applications that require the preparation of these compounds in an efficient manner, which nowadays, also involves taking into consideration sustainability issues. In this context, we use ball milling mechanochemistry and sonochemistry for the rational development of synthetic strategies for the sustainable preparation of metalloporphyrins. Zinc, copper, cobalt...

Correction: Deep in blue with green chemistry: influence of solvent and chain l...

Reações multicomponente: uma ferramenta valiosa na descoberta e produção de fár...

Multicomponent reactions (MCRs) allow the combination, in one step, of three or more reactants in one product, being a very useful tool for the generation of new compound libraries since they lead to a wide structural diversity. These reactions are characterized by their high atom economy, hence being excellent models for sustainable chemistry methodologies throughout the drug discovery, development and product...

Tryptanthrin from indigo: Synthesis, excited state deactivation routes and effi...

The microwave-assisted synthesis of tryptanthrin from indigo in mild oxidation conditions, and a comprehensive study of the excited state properties of this compound in a variety of solvents with different polarity and viscosity values at room and low temperatures are reported. In contrast with indigo, emission of the triplet state of tryptanthrin is observed with a very efficient singlet oxygen sensitization q...