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Neonatal Apex Resection Triggers Cardiomyocyte Proliferation, Neovascularizatio...
Sampaio-Pinto, Vasco; Rodrigues, Sílvia C.; Laundos, Tiago L.; Silva, Elsa D.; Vasques-Nóvoa, Francisco; Silva, Ana C.; Cerqueira, Rui J.So far, opposing outcomes have been reported following neonatal apex resection in mice, questioning the validity of this injury model to investigate regenerative mechanisms. We performed a systematic evaluation, up to 180 days after surgery, of the pathophysiological events activated upon apex resection. In response to cardiac injury, we observed increased cardiomyocyte proliferation in remote and apex regions,...
Date: 2018
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Origin: Repositório da Universidade de Lisboa