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In vitro and in vivo anti-malarial activity of plants from the Brazilian Amazon

Lima, Renata Braga Souza; Rocha Silva, Luiz F.; Melo, Márcia R.S.; Costa, Jacqueline S.; Picanço, Neila Soares; Lima, Emerson Silva

Background: The anti-malarials quinine and artemisinin were isolated from traditionally used plants (Cinchona spp. and Artemisia annua, respectively). The synthetic quinoline anti-malarials (e.g. chloroquine) and semi-synthetic artemisinin derivatives (e.g. artesunate) were developed based on these natural products. Malaria is endemic to the Amazon region where Plasmodium falciparum and Plasmodium vivax drug-re...

Date: 2020   |   Origin: Oasisbr

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