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Management of Asymptomatic Sporadic Nonfunctioning Pancreatic Neuroendocrine Ne...

Partelli, S; Ramage, J; Massironi, S; Zerbi, A; Kim, H; Niccoli, P; Panzuto, F; Landoni, L; Tomazic, A; Ibrahim, T; Kaltsas, G; Bertani, E; Sauvanet, A

Introduction: The optimal treatment for small, asymptomatic, nonfunctioning pancreatic neuroendocrine neoplasms (NF-PanNEN) is still controversial. European Neuroendocrine Tumor Society (ENETS) guidelines recommend a watchful strategy for asymptomatic NF-PanNEN <2 cm of diameter. Several retrospective series demonstrated that a non-operative management is safe and feasible, but no prospective studies are availa...


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