3 documents found, page 1 of 1
Recommendations from a Portuguese Expert Group for Discontinuation of Tyrosine ...
Almeida, Antonio; Pierdomenico, Francesca; Guerrero, Blanca Polo; Saraiva, Filipa; Montalvão, Ana; Coutinho, Jorge; Mariz, Mário; Melo, TeresaUntil recently, the main goal of chronic myeloid leukemia therapy was disease control with the best overall survival, which required lifelong treatment. However, currently, the treatment-free remission concept is becoming an important goal in clinical practice, and several tyrosine kinase inhibitors discontinuation studies have shown that round 50% of patients with a durable deep molecular response beyond majo...
Negative MR4·0 chronic myeloid leukaemia and its possible implications for trea...
Cerveira, Nuno; Diamond, Joana; Matos, Sónia; Amorim, Maria L; Coucelo, Margarida; Bizarro, Susana; Simões, Ana Teresa; Pierdomenico, FrancescaABL1 tyrosine kinase inhibitors (TKI) have dramatically improved the outcome for chronic myeloid leukaemia (CML) patients, resulting in a life expectancy that approaches that of the general population. Nevertheless, lifelong TKI therapy may have consequences, including chronic adverse events that can substantially impact patients’ quality of life, adherence to therapy and treatment success. Recently, several cl...
Burkitt's Lymphoma in a pregnant woman: case report and review of the literature
Zagalo, Carlos; Pierdomenico, Francesca; Cabeçadas, José; Santos, Pedro David"Burkitt’s lymphoma (BL) is an aggressive B-cellmalignancy with very high proliferation rate,more common inmales than females. Here, we describe a case of Burkitt’s lymphoma in a 24-week pregnant woman with cervical and abdominal involvement. The common genetic event of virtually all BL is a reciprocal chromosomal translocation involving the proto-oncogene MYC and one of the Ig gene heavy or light chain loci. S...