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Variation in follow-up for children born very preterm in Europe

Seppänen, AV; Barros, H; Draper, ES; Petrou, S; Andronis, L; Kim, S; Maier, RF; Pedersen, P; Gadzinowski, J; Pierrat, V; Sarrechia, I; Lebeer, J

Background Children born very preterm (<32 weeks of gestation) face high risks of neurodevelopmental and health difficulties compared with children born at term. Follow-up after discharge from the neonatal intensive care unit is essential to ensure early detection and intervention, but data on policy approaches are sparse. Methods We investigated the characteristics of follow-up policy and programmes in 11 Euro...


Health-related quality of life at 5 years of age for children born very preterm...

Kim, SW; Tian, X; Andronis, L; Maier, RF; Varendi, H; Seppänen, A-V; Siljehav, V; Draper, ES; Zeitlin, J; Petrou, S; Seppänen, AV; El Rafei, R

Background: This study aimed to investigate the health-related quality of life (HRQoL) at 5 years of age of European children born very preterm across multi-dimensional outcomes by presence and severity of congenital anomalies. Methods: The study used data from a European cohort of children born very preterm (<32 weeks of gestation) and followed up to 5 years of age (N = 3493). Multilevel Ordinary Least Squares...


Developmental motor problems and health-related quality of life in 5-year-old c...

Aubert, AM; Costa, R; Johnson, S; Ådén, U; Pierrat, V; Cuttini, M; Männamaa, M; Sarrechia, I; Lebeer, J; Van Heijst, AF; Maier, RF; Sentenac, M

Aim To measure the association between cerebral palsy (CP) and non-CP-related movement difficulties and health-related quality of life (HRQoL) among 5-year-old children born extremely preterm (<28 weeks gestational age). Method We included 5-year-old children from a multi-country, population-based cohort of children born extremely preterm in 2011 to 2012 in 11 European countries (n = 1021). Children without CP ...


Prediction of movement difficulties at 5 years from parent report at 2 years in...

Costa, R; Aubert, AM; Seppänen, AV; Ådén, U; Sarrechia, I; Zemlin, M; Cuttini, M; Männamaa, M; Pierrat, V; van Heijst, A; Barros, H; Zeitlin, J

AimTo assess the predictive validity of parent-reported gross motor impairment (GMI) at age 2 years to detect significant movement difficulties at age 5 years in children born extremely preterm. MethodData were from 556 children (270 males, 286 females) born at less than 28 weeks' gestation in 2011 to 2012 in 10 European countries. Parent report of moderate/severe GMI was defined as walking unsteadily or unable...


Risk factors for cerebral palsy and movement difficulties in 5-year-old childre...

Aubert, AM; Costa, R; Johnson, S; Aden, U; Cuttini, M; Koopman-Esseboom, C; Lebeer, J; Varendi, H; Zemlin, M; Pierrat, V; Zeitlin, J

BackgroundMotor impairment is common after extremely preterm (EPT, <28 weeks' gestational age (GA)) birth, with cerebral palsy (CP) affecting about 10% of children and non-CP movement difficulties (MD) up to 50%. This study investigated the sociodemographic, perinatal and neonatal risk factors for CP and non-CP MD.MethodsData come from a European population-based cohort of children born EPT in 2011-2012 in 11 c...


Motor-related health care for 5-year-old children born extremely preterm with m...

Costa, R; Aubert, AM; Seppänen, A-V; Ådén, U; Sarrechia, L; Zemlin, M; Cuttini, M; Männamaa, M; Pierrat, V; van Heijst, A; Barros, H; Johnson, S

Aim: To (1) determine the proportion of 5-year-old children born extremely preterm (EPT) with movement difficulties including cerebral palsy (CP) and the proportion of these children receiving motor-related health care (MRHC), and (2) describe factors associated with receiving MRHC. Method: Children born before 28 weeks’ gestation in 2011 to 2012 in 11 European countries were assessed with the Movement Assessme...


Movement Difficulties at Age Five Among Extremely Preterm Infants

Aubert, AM; Costa, R; Ådén, U; Cuttini, M; Männamaa, M; Pierrat, V; Sarrechia, I; van Heijst, AF; Zemlin, M; Johnson, S; Zeitlin, J

BACKGROUND AND OBJECTIVES: Children born extremely preterm (EPT), <28 weeks' gestational age, face higher risks of movement difficulties than their term-born peers. Studies report varying prevalence estimates and prognostic factors identifying children who could benefit from early intervention are inconsistent. This study investigated the prevalence of movement difficulties in children born EPT and associated r...


Managing mother’s own milk for very preterm infants in neonatal units in 11 Eur...

Rodrigues, C; Zeitlin, J; Wilson, E; Toome, L; Cuttini, M; Maier, RF; Pierrat, V; Barros, H; EPICE Research Group

Feeding with human milk has been recognised as an essential component of newborn care and is especially important for infants born very preterm (VPT, below 32 weeks of gestation) who face higher risks of adverse outcomes. WHO recommends that infants who cannot be fed mother's own milk (MOM) should receive donor human milk. Direct feeding at the breast takes time to establish after VPT birth and procedures are r...


Cohort Profile: the Etude Epidémiologique sur les Petits Ages Gestationnels-2 (...

Lorthe, E; Benhammou, V; Marchand-Martin, L; Pierrat, V; Lebeaux, C; Durox, M; Goffinet, F; Kaminski, M; Ancel, PY; EPIPAGE-2 Study Group

Medical practices and the organization of care vary widely across countries and have markedly evolved over the past two decades. The prognosis of very preterm infants has changed accordingly, raising new questions and requiring new assessments. We therefore set up the EPIPAGE-2 cohort, a new longitudinal study of preterm infants, with the following objectives: to provide actualized estimates of short- and long-...


The impact of choice of norms on classification of motor impairment for childre...

Costa, R; Johnson, S; Cuttini, M; Pierrat, V; Sarrechia, I; Barros, H; Zeitlin, J

Background. The Movement Assessment Battery for Children-Second Edition (Movement ABC-2) is widely used to assess children's motor function, yet there is a lack of normative data for many countries. Aims. To assess the extent to which the application of different population reference norms for the Movement ABC-2 affects the classification and prevalence of motor impairment. Design. Data were obtained from two P...


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