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Environmental and societal factors associated with COVID-19-related death in pe...

Izadi, Zara; Gianfrancesco, Milena A.; Schmajuk, Gabriela; Jacobsohn, Lindsay; Katz, Patricia; Rush, Stephanie; Ja, Clairissa; Taylor, Tiffany

Background: Differences in the distribution of individual-level clinical risk factors across regions do not fully explain the observed global disparities in COVID-19 outcomes. We aimed to investigate the associations between environmental and societal factors and country-level variations in mortality attributed to COVID-19 among people with rheumatic disease globally. Methods: In this observational study, we de...


Clinical spectrum time course in non-Asian patients positive for anti-MDA5 anti...

Cavagna, Lorenzo; Meloni, Federica; Meyer, Alain; Sambataro, Gianluca; Belliato, Mirko; De Langhe, Ellen; Cavazzana, Ilaria; Pipitone, Nicolò

Objectives: To define the clinical spectrum time-course and prognosis of non-Asian patients positive for anti-MDA5 antibodies. Methods: We conducted a multicentre, international, retrospective cohort study. Results: 149 anti-MDA5 positive patients (median onset age 53 years, median disease duration 18 months), mainly females (100, 67%), were included. Dermatomyositis (64, 43%) and amyopathic dermatomyositis (47...


Idiopathic inflammatory myopathies : state of the art on clinical practice guid...

Meyer, Alain; Scirè, Carlo Alberto; Talarico, Rosaria; Alexander, Tobias; Amoura, Zahir; Avcin, Tadej; Barsotti, Simone; Beretta, Lorenzo

Idiopathic inflammatory myopathies (IIMs) encompass a heterogeneous group of rare autoimmune diseases characterised by muscle weakness and inflammation, but in antisynthetase syndrome arthritis and interstitial lung disease are more frequent and often inaugurate the disease. Clinical practice guidelines (CPGs) have been proposed for IIMs, but they are sparse and heterogeneous. This work aimed at identifying: i)...


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