17 documents found, page 1 of 2
Case report of a child with influenza and fatal community-associated methicilli...
Boettger,Bruno Cruz; Rezende,Thais Freitas Teles; Teixeira,Nathalia Bibiana; Pignatari,Antonio Carlos Campos; Kiffer,Carlos Roberto VeigaAbstract In the present study, we report the incidence of septic shock syndrome associated with methicillin-resistant Staphylococcus aureus in a child who initially presented influenza-like illness and developed septic shock shortly after 48 h of hospitalization, and eventually died within a few hours of the onset of sepsis. S. aureus isolated from the blood culture was characterized as the community-associated...
Direct matrix-assisted laser desorption ionization time-of-flight mass spectrom...
Quiles,Milene Gonçalves; Boettger,Bruno Cruz; Inoue,Fernanda Matsiko; Monteiro,Jussimara; Santos,Daniel Wagner; Ponzio,Vinicius; Carlesse,FabianneABSTRACT Bloodstream infections (BSIs) are serious infections associated with high rates of morbidity and mortality. Every hour delay in initiation of an effective antibiotic increases mortality due to sepsis by 7%. Turnaround time (TAT) for conventional blood cultures takes 48 h, forcing physicians to streamline therapy by exposing patients to broad-spectrum antimicrobials. Our objective was (1) to evaluate th...
Tailoring antimicrobials in febrile neutropenia: using faster diagnostic and co...
Souza,Ingvar Ludwig Augusto de; Quiles,Milene Gonçalves; Boettger,Bruno Cruz; Pignatari,Antonio Carlos Campos; Cappellano,PaolaABSTRACT Febrile Neutropenia represents a medical emergency and the use of appropriate antimicrobial therapy is essential for a better outcome. Although being time-consuming, conventional cultures and antimicrobial susceptibility tests remain the golden standard practices for microbiology identification. Final reports are typically available within several days. Faster diagnostic tools, such as species identifi...
Trends of 9,416 multidrug-resistant Gram-negative bacteria
Oliveira,Viviane Decicera Colombo; Rubio,Fernando Góngora; Almeida,Margarete Teresa Gottardo; Nogueira,Mara Corrêa LellesSummary Objective: a resistance of hospital-acquired bacteria to multiple antibiotics is a major concern worldwide. The objective of this study was to investigate multidrugresistant (MDR) bacteria, clinical specimens, origin of specimen and trends, and correlate these with bacterial sensitivity and consumption of antimicrobials. Methods: 9,416 bacteria of nosocomial origin were evaluated in a tertiary hospital,...
Pharmacodynamic profiling of commonly prescribed antimicrobial drugs against Es...
Cuba,Gabriel Trova; Pignatari,Antonio Carlos Campos; Patekoski,Katya Silva; Luchesi,Lucimila Jorge; Kiffer,Carlos Roberto VeigaSince antimicrobial resistance among uropathogens against current first line agents has affected the management of severe urinary tract infection, we determined the likelihood that antibiotic regimens achieve bactericidal pharmacodynamic exposures using Monte Carlo simulation for five antimicrobials (ciprofloxacin, ceftriaxone, piperacillin/tazobactam, ertapenem, and meropenem) commonly prescribed as initial em...
The first report of infection with Klebsiella pneumoniae carrying the bla kpc g...
Chang,Marilene Rodrigues; Biberg,Camila Arguelo; Lopes,Fernando Aguilar; Tetila,Andyane Freitas; Pignatari,Antonio Carlos CamposThe increased frequency and dissemination of enterobacteria resistant to various antimicrobials is currently worldwide concern. In January 2010, a 94-year-old patient with chronic lymphocytic leukemia was admitted to the University Hospital. This patient died 21 days after hospitalization due to the clinical worsening. Klebsiella pneumoniae producing of extended-spectrum β-lactamases (ESBLs) was isolated of uri...
Proposta sobre uso de dados de receitas de antimicrobianos retidas: a experiênc...
Camargo,Eduardo Celso Gerbi; Kiffer,Carlos Roberto Veiga; Pignatari,Antonio Carlos Campos; Shimakura,Silvia Emiko; Ribeiro Jr,Paulo JustinianoA presente nota pesquisa demonstra que o uso das informações de receituário ou prescrição médica tem fundamental valor para a compreensão das correlações da dinâmica da resistência bacteriana comunitária. Além disso, a análise dos dados gerada pode ajudar a estabelecer medidas e políticas de saúde pública mais adequadas para o controle e a otimização do consumo de antimicrobianos. Para isso, o artigo usa como b...
Spatial exploration of Streptococcus pneumoniae clonal clustering in São Paulo,...
Mouro,Amilton; Kiffer,Carlos; Koga,Paula C.M; Monteiro,Antonio M.V; Camargo,Eduardo Celso Gerbi; Pignatari,Antonio Carlos CamposOBJECTIVES: To examine the spatial distribution of Streptococcus pneumoniae and its clonal patterns collected between 2002 and 2006 in São Paulo, Brazil. METHODS: As part of an observational study in São Paulo city, Brazil, S. pneumoniae isolates routinely cultured from blood, respiratory specimens, or cerebrospinal and other profound fluids were selected. Additionally, only isolates with either penicillin (PEN...
Pneumonia necrotizante por Staphylococcus aureus resistente à meticilina
d'Azevedo,Pedro Alves; Inoue,Fernanda Matsiko; Andrade,Soraya Sgambatti; Tranchesi,Regina; Pignatari,Antonio Carlos CamposO objetivo desse estudo foi descrever um caso de pneumonia necrotizante por Staphylococcus aureus resistente a meticilina. A amostra foi isolada em hemocultura coletada menos de 48 horas da admissão hospitalar. A paciente era previamente hígida quando do início do processo infeccioso. O isolado possuía o gene mecA, com "staphylococcal cassette chromosome mec" tipo IVa". A presença de Staphylococcus aureus carre...
Molecular biology applied to the laboratory diagnosis of bacterial endophthalmitis
Bispo,Paulo José Martins; Höfling-Lima,Ana Luisa; Pignatari,Antonio Carlos CamposBacterial endophthalmitis is a serious but uncommon intraocular infection which frequently results in vision loss. Early diagnosis and appropriate therapy are associated with better visual outcome. Conventional microbiological methods are currently used for microbiological characterization of eyes with suspected endophthalmitis. However, the sensitivity of bacterial detection from aqueous and vitreous humor usi...