3 documents found, page 1 of 1
The effect of coping on the relationship between work-family conflict and stres...
Sousa, C. de.; Viseu, J.; Pimenta, A. C.; Vinagre, H.; Ferreira, J.; Matavelli, R.; José, H.; Sousa, L.; Romana, F. A.; Valentim, O.The challenges experienced in the context of the pandemic have required a significant reconciliation between work and family domains due to confinement and the need to spend more time at home, which may have increased the levels of stress, anxiety, and depression, making it necessary to use resilient coping strategies to overcome the difficulties felt. This study examined the effect of resilient coping on the r...
Evolution of Drug Resistance: Insight on TEM β-Lactamases Structure and Activit...
Pimenta, A. C.; Fernandes, Rúben; Moreira, I. S.Since the discovery of the first penicillin bacterial resistance to β-lactam antibiotics has spread and evolved promoting new resistances to pathogens. The most common mechanism of resistance is the production of β-lactamases that have spread thorough nature and evolve to complex phenotypes like CMT type enzymes. New antibiotics have been introduced in clinical practice, and therefore it becomes necessary a con...
Ligand-Induced structural changes in TEM‑1 probed by molecular dynamics and rel...
Pimenta, A. C.; Martins, J. M.; Fernandes, Rúben; Moreira, I. S.The TEM family of enzymes has had a crucial impact on the pharmaceutical industry due to their important role in antibiotic resistance. Even with the latest technologies in structural biology and genomics, no 3D structure of a TEM- 1/antibiotic complex is known previous to acylation. Therefore, the comprehension of their capability in acylate antibiotics is based on the protein macromolecular structure uncomple...