2 documents found, page 1 of 1
Coagulation disorders in adults with severe acute respiratory syndrome coronavi...
Pereira Costa, Susana; Lopes Antunes, Inês; Gomes, Ana Margarida; Ho, Cláudia; Lemos Caldas, Mafalda; Marques, Ana Rute; Monteiro Pereira, AnaObjectives: To summarize published information on coagulation disorders in patients with SARS-CoV-2 infection, namely its characteristics, pathophysiology, diagnosis, and response to anticoagulant or antiplatelet therapy, either prophylactic or therapeutic. Methods: A scoping review was conducted according to both Joanna Briggs Institute Guidelines on Scoping Reviews and Preferred Reporting Items for Systemat...
Adult B-cell acute lymphoblastic leukemia cells display decreased PTEN activity...
Gomes, Ana Margarida; Soares, Maria Vieira; Ribeiro, Patrícia; Caldas, Joana; Póvoa, Vanda; Martins, Leila; Melão, Alice; Serra-Caetano, AnaAdult B-cell acute lymphoblastic leukemia remains a major therapeutic challenge, requiring a better characterization of the molecular determinants underlying disease progression and resistance to treatment. Here, using a phospho-flow cytometry approach we show that adult diagnostic B-cell acute lymphoblastic leukemia specimens display PI3K/Akt pathway hyperactivation, irrespective of their BCR-ABL status and de...