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Rationale and Methodological Approach Underlying the Development of the Sequent...

Moreno, Rui; Rhodes, Andrew; Ranzani, Otavio; Salluh, Jorge; Berger-Estilita, Joana; Coopersmith, Craig M.; Juffermans, Nicole P.; Laffey, John

Importance: The Sequential Organ Failure Assessment (SOFA) score was published in 1996 to describe organ dysfunction in critically ill adult patients in a readily quantifiable and sequential manner. Considerable changes have occurred over the last 3 decades in the use of organ support drugs and devices and in patient outcomes, necessitating revision of the score. Objectives: To develop definitions of organ dysf...


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