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Synthesis, Copper(II) Binding, and Antifungal Activity of Tertiary N-Alkylamine...

Pissarro, Teresa; Malta-Luís, Cláudia; Ferreira, Luana; Pimentel, Catarina; Lima, Luís M.P.

Publisher Copyright: © 2024 by the authors.; The rise in antifungal resistance among medically important fungi causing severe infectious diseases has underscored the urgent need for developing more effective antifungal agents. Growing evidence suggests that compounds combining functional antifungal groups with metals are promising candidates and may well be the key to addressing this global challenge. In this w...


A one-step low-cost molecular test for SARS-CoV-2 detection suitable for commun...

Da Silva, Sofia M.; Amaral, Catarina; Malta-Luís, Cláudia; Grilo, Diana; Duarte, Americo G.; Morais, Inês; Afonso, Gonçalo; Faria, Nuno; Antunes, Wilson

Funding Information: This work was supported by (i) Project LISBOA-01-0145-FEDER-007660 (\u2018Microbiologia Molecular, Estrutural e Celular\u2019) funded by FEDER \u2018Fundo Europeu de Desenvolvimento Regional\u2019 funds through COMPETE2020\u2014\u2018Programa Operacional Competitividade e Internacionaliza\u00E7\u00E3o\u2019 (POCI), (ii) \u2018Funda\u00E7\u00E3o para a Ci\u00EAncia e a Tecnologia\u2019 (FCT)...


Antifungal Potential of Marine Organisms of the Yucatan Peninsula (Mexico) agai...

Pech-Puch, Dawrin; Grilo, Diana; Calva-Pérez, Susana Eunice; Pedras, Andreia; Villegas-Hernández, Harold; Guillén-Hernández, Sergio; Díaz-Gamboa, Raúl

Funding Information: The authors acknowledge the Fundação para a Ciência e a Tecnologia, I.P., through (i) MOSTMICRO-ITQB R&D Unit (UIDB/04612/2020), (ii) LS4FUTURE Associated Laboratory (LA/P/0087/2020), (iii) POPH (Programa Operacional Potencial Humano), and FSE (European Social Fund) CEEC 2017 Initiative (to O.A.L.-R.) and (iv) PhD fellowship to A.P. (SFRH/BD/148854/2019). D.P.-P was the recipient of a postd...


Copper Acts Synergistically With Fluconazole in Candida glabrata by Compromisin...

Gaspar-Cordeiro, Ana; Amaral, Catarina; Pobre, Vânia; Antunes, Wilson; Petronilho, Ana; Paixão, Paulo; Matos, António P.; Pimentel, Catarina

Funding Information: This work was supported by (1) Project LISBOA-01-0145-FEDER-007660 (“Microbiologia Molecular, Estrutural e Celular”) funded by FEDER funds through COMPETE2020 – “Programa Operacional Competitividade e Internacionalização” (POCI); (2) “Fundação para a Ciência e a Tecnologia” (FCT) through programme IF (IF/00124/2015) to CP; (3) the European Union’s Horizon 2020 Research and Innovation Progra...


A molecular test based on RT-LAMP for rapid, sensitive and inexpensive colorime...

Amaral, Catarina; Antunes, Wilson; Moe, Elin; Duarte, Américo G.; Lima, Luís M.P.; Santos, Cristiana; Gomes, Inês L.; Afonso, Gonçalo S.

Funding Information: We thank the members of the COVID-19 task force of ITQB NOVA and Mariana Pinho for helpful discussions and suggestions. In particular, we thank Claudio M. Soares and Adriano O. Henriques for their unconditional support and invaluable help in making this work possible. The authors acknowledge the assistance of Paula Chi-cau, ITQB NOVA, in the development of the saliva test and are grateful t...


An internal promoter drives the expression of a truncated form of ccc1 capable ...

Amaral, Catarina; Vicente, Cristina Teixeira; Caetano, Soraia Marques; Gaspar-Cordeiro, Ana; Yang, Yang; Cloetens, Peter; Romão, Célia V.

Funding Information: This work was supported by Project LISBOA-01-0145-FEDER-007660 (?Microbiologia Molecular, Estrutural e Celular?) funded by FEDER funds through COMPETE2020??Programa Operacional Competitividade e Internacionaliza??o? (POCI); ?Funda??o para a Ci?ncia e a Tecnologia? (FCT) grants EXPL/BIA-MIC/2525/2013 and programme IF (IF/00124/2015) to C.P.; grant PTDC/BIA-BQM/31317/2017 to C.V.R.; the Europ...


Yeast AP-1 like transcription factors (Yap) and stress response

Rodrigues-Pousada, Claudina; Devaux, Frédéric; Caetano, Soraia M.; Pimentel, Catarina; da Silva, Sofia; Cordeiro, Ana Carolina; Amaral, Catarina

Yeast adaptation to stress has been extensively studied. It involves large reprogramming of genome expression operated by many, more or less specific, transcription factors. Here, we review our current knowledge on the function of the eight Yap transcription factors (Yap1 to Yap8) in Saccharomyces cerevisiae, which were shown to be involved in various stress responses. More precisely, Yap1 is activated under ox...


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