41 documents found, page 1 of 5
Allergic inflammation triggers dyslipidemia via IgG signalling
Fernández-Gallego, Nieves; Castillo-González, Raquel; Moreno-Serna, Lucía; García-Cívico, Antonio J.; Sánchez-Martínez, Elisa; López-Sanz, CeliaBackground: Allergic diseases begin early in life and are often chronic, thus creating an inflammatory environment that may precede or exacerbate other pathologies. In this regard, allergy has been associated to metabolic disorders and with a higher risk of cardiovascular disease, but the underlying mechanisms remain incompletely understood. Methods: We used a murine model of allergy and atherosclerosis, differ...
Microbial conjugated linolenic acid-enriched fermented milk using lipase-hydrol...
Fontes, Ana Luiza; Pimentel, Lígia L.; Monteiro, Maria João P.; Domingues, M. Rosário; Rodríguez-Alcalá, Luis Miguel; Gomes, Ana MariaThe bioactive conjugated linolenic acid (CLNA) can be microbiologically produced by different probiotic strains when in the presence of α-linolenic acid (α-LNA). Food matrices are a good vector, such as has been previously demonstrated with fermented milk enriched with microbial CLNA by Bifidobacterium breve DSM 20091 from lipase-hydrolyzed flaxseed oil. The aim of the present work was to further assess the nut...
Modified cellulose nanocrystals encapsulating cannabigerol: a step forward in c...
Casanova, Francisca; Pereira, Carla F.; Ribeiro, Alessandra B.; Castro, Pedro M.; Martins, Eva; Freixo, Ricardo; Tavares-Valente, DianaCannabigerol (CBG) from Cannabis sativa L. is known for its anti-inflammatory, antibacterial, and antioxidant properties, showing potential against intestinal inflammation. However, its lipophilic nature limits its absorption and stability. Researchers have explored cellulose nanocrystals (CNCs) to deliver lipophilic compounds and enhance their biological outcomes. This study investigated the capability of modi...
Differential lipid accumulation on HepG2 cells triggered by palmitic and linole...
Teixeira, Francisca S.; Pimentel, Lígia L.; Vidigal, Susana S. M. P.; Azevedo-Silva, João; Pintado, Manuela E.; Rodríguez-Alcalá, Luís M.Lipid metabolism pathways such as β-oxidation, lipolysis and, lipogenesis, are mainly associated with normal liver function. However, steatosis is a growing pathology caused by the accumulation of lipids in hepatic cells due to increased lipogenesis, dysregulated lipid metabolism, and/or reduced lipolysis. Accordingly, this investigation hypothesizes a selective in vitro accumulation of palmitic and linoleic fa...
Evolution of qualitative and quantitative lipid profiles of high-pressure-proce...
Inácio, Rita S.; Rodríguez-Alcalá, Luís M.; Pimentel, Lígia L.; Saraiva, Jorge A.; Gomes, Ana M. P.High-pressure processing (HPP) can be used as a nonthermal pasteurization technique to overcome microbial safety issues of the raw ewes’ milk Serra da Estrela cheese without negatively influencing its quality, in particular, the lipid composition partly responsible for Serra da Estrela cheese’s sensorial and textural attributes. The aim of this work was to assess HPP’s effect (600 MPa/6 min and 450 MPa/6 and 9 ...
Cannabidiol and cannabigerol exert antimicrobial activity without compromising ...
Luz-Veiga, Mariana; Amorim, Manuela; Pinto-Ribeiro, Inês; Oliveira, Ana L. S.; Silva, Sara; Pimentel, Lígia L.; Rodríguez-Alcalá, Luís M.Cannabidiol (CBD) and cannabigerol (CBG) are two pharmacologically active phytocannabinoids of Cannabis sativa L. Their antimicrobial activity needs further elucidation, particularly for CBG, as reports on this cannabinoid are scarce. We investigated CBD and CBG’s antimicrobial potential, including their ability to inhibit the formation and cause the removal of biofilms. Our results demonstrate that both molecu...
Novel lipids to regulate obesity and brain function: comparing available eviden...
Teixeira, Francisca S.; Costa, Paula T.; Soares, Ana M. S.; Fontes, Ana Luiza; Pintado, Manuela E.; Vidigal, Susana S. M. P.; Pimentel, Lígia L.Lipid molecules, such as policosanol, ergosterol, sphingomyelin, omega 3 rich phosphatidylcholine, α-tocopherol, and sodium butyrate, have emerged as novel additions to the portfolio of bioactive lipids. In this state-of-the-art review, we discuss these lipids, and their activity against obesity and mental or neurological disorders, with a focus on their proposed cellular targets and the ways in which they prod...
Induced autolysis of engineered yeast residue as a means to simplify downstream...
Fundo, Joana F.; Deuchande, Teresa; Rodrigues, Daniela A.; Pimentel, Lígia L.; Vidigal, Susana S. M. P.; Rodríguez-Alcalá, Luís M.; Pintado, Manuela E.The objective of this work was to study the efficiency of different autolysis processes, combining different temperatures and pH conditions, when applied to a genetically engineered yeast residue. The determination of the supernatants’ dry weight showed that the autolysis time could be reduced to half, from 4 to 2 h, if the residue pH was increased from 5 to 8 at 50 °C (18.20% for 4 h and 18.70% for 2 h with a ...
Toward sustainable wax extraction from the Saccharum officinarum L. filter cake...
Teixeira, Francisca S.; Costa, Paula T.; Vidigal, Susana S.; Pintado, Manuela; Pimentel, Lígia L.; Rodríguez-Alcalá, Luís M.Saccharum officinarum L. exploitation and processing result in different byproducts, such as filter cake (FC). This study aimed to establish the most suitable experimental conditions to obtain lipophilic bioactive compounds from FC industrial residues, considering their high efficiency, cost-effectiveness, extraction yield, composition, and physicochemical properties. Results indicated that the most appropriate...
Allergic inflammation triggers dyslipidemia via IgG signalling
Fernández-Gallego, Nieves; Castillo-González, Raquel; Moreno-Serna, Lucía; García-Cívico, Antonio J.; Sánchez-Martínez, Elisa; López-Sanz, CeliaAllergic diseases begin early in life and are often chronic, thus creating an inflammatory environment that may lead to metabolic disorders, although the underlying mechanisms remain incompletely understood. Here, we show that allergic inflammation induces diet-independent dyslipidemia in a mouse model of allergy and atherosclerosis. Using untargeted lipidomics in mouse plasma, we found that allergic inflammati...