3 documents found, page 1 of 1
Role of genetic polymorphisms on neuroplasticity pathways in a cohort of Portug...
Santos, M.; Carvalho, S.; Lima, L.; Mota-Pereira, J.; Pimentel, P.; Correia, D.; Maia, D.; Gomes, S.; Cruz, A.; Medeiros, R.Growing evidence suggests the implication of brain plasticity in antidepressant drug (AD) efficacy. Several authors have been pointing out the role of the BDNF-TrkB signaling pathway, including the downstream kinases Akt and ERK, and the mTOR pathway in neuroplasticity [1-3]. Furthermore, the prediction of AD response phenotypes of depressed patients treated with AD drugs remains a challenge for clinicians. Alt...
Born green: Drivers and competencies of green entrepreneurship
Pimentel, P.; Sousa, M. J.Sustainable development is one of the most prominent discussions of our times and promoting green new ventures can help reduce ecological footprints and meet the climate change goals. Despite its importance for the next decades, the study of green entrepreneurship (GE) is still very poor and being an emerging field of study can be considered still in its infancy. (Demirel et al, 2019; Sher et al, 2020). The cur...
Influence of Il-18 genetic polymorphisms in antidepressant treatment phenotypes
Santos, Marlene; Carvalho, S.; Lima, L.; Mota-Pereira, J.; Pimentel, P.; Maia, D.; Correia, D.; Gomes, S.; Cruz, Agostinho; Medeiros, R.Recent studies suggested that immune activation and cytokines might be involved in depression. The proinflammatory cytokine interleukin-18 (IL-18) is less reported in depression but is still relevant since it is expressed in the brain and serum levels of IL-18 have been found to be increased in patients with moderate to severe depression. Therefore, it seems reasonable that IL-18 promoter SNPs may have an effec...