4 documents found, page 1 of 1
Cell-based platform to test Aquaporins as targets for anticancer drug discovery
Pimpão, CatarinaAquaporins (AQPs) are transmembrane protein channels that facilitate the bidirectional transport of water, glycerol, H2O2, and other small solutes across cell membranes, contributing to essential physiological processes such as renal water reabsorption, skin hydration and metabolism. However, AQPs have been implicated in various pathological conditions, with their dysregulated expression being associated with m...
Glutamine and cystine-enriched diets modulate aquaporins gene expression in the...
da Silva, Inês V.; Soares, Bárbara P.; Pimpão, Catarina; Pinto, Rui M. A.; Costa, Teresa; Freire, João P. B.; Corrent, EtienneABSTRACT - The regulation of glycerol permeability in the gastrointestinal tract is crucial to control fat deposition, lipolysis and gluconeogenesis. Knowing that the amino acid glutamine is a physiological regulator of gluconeogenesis, whereas cystine promotes adiposity, herein we investigated the effects of dietary supplementation with glutamine and cystine on the serum biochemical parameters of piglets fed o...
Glutamine and cystine-enriched diets modulate aquaporins gene expression in the...
Silva, Inês Vieira; Soares, Bárbara P.; Pimpão, Catarina; Pinto, Rui M.A.; Costa, Teresa; Freire, JoãoThe regulation of glycerol permeability in the gastrointestinal tract is crucial to control fat deposition, lipolysis and gluconeogenesis. Knowing that the amino acid glutamine is a physiological regulator of gluconeogenesis, whereas cystine promotes adiposity, herein we investigated the effects of dietary supplementation with glutamine and cystine on the serum biochemical parameters of piglets fed on amino aci...
The aquaporin-3-inhibiting potential of polyoxotungstates
Pimpão, Catarina; da Silva, Inês V.; Mósca, Andreia F.; Pinho, Jacinta O.; Gaspar, Maria Manuela; Gumerova, Nadiia I.; Rompel, AnnettePolyoxometalates (POMs) are of increasing interest due to their proven anticancer activities. Aquaporins (AQPs) were found to be overexpressed in tumors bringing particular attention to their inhibitors as anticancer drugs. Herein, we report for the first time the ability of polyoxotungstates (POTs), such as of Wells-Dawson P2W18, P2W12, and P2W15, and Preyssler P5W30 structures, to affect aquaporin-3 (AQP3) ac...