7 documents found, page 1 of 1
Alpha-thalassemia due to novel deletions and complex rearrangements in the subt...
Ferrão, José; Silva, Marisa; Gonçalves, Lúcia; Gomes, Susana; Loureiro, Pedro; Coelho, Andreia; Miranda, Armandina; Seuanes, Filomena; Batalha Reis, AnaIntroduction: Inherited deletions removing the α-globin genes and/or their upstream regulatory elements (MCSs) give rise to alpha-thalassemia, one of the most common genetic recessive disorders worldwide. The pathology is characterized by microcytic hypochromic anemia due to reduction of the α-globin chain synthesis, which are essential for hemoglobin tetramerization. Material and Methods: In order to clarify t...
Widening the spectrum of deletions and molecular mechanisms underlying alpha-th...
Ferrão, José; Silva, Marisa; Gonçalves, Lúcia; Gomes, Susana; Loureiro, Pedro; Coelho, Andreia; Miranda, Armandina; Seuanes, Filomena; Reis, Ana BatalhaInherited deletions of α-globin genes and/or their upstream regulatory elements (MCSs) give rise to α-thalassemia, an autosomal recessive microcytic hypochromic anemia. In this study, Multiplex Ligation-dependent Probe Amplification performed with commercial and synthetic engineered probes, Gap-PCR, and DNA sequencing were used to characterize lesions in the subtelomeric region of the short arm of chromosome 16...
Alpha-thalassemia due to novel deletions and complex rearrangements in the subt...
Ferrão, José; Silva, Marisa; Gonçalves, Lúcia; Gomes, Susana; Loureiro, Pedro; Coelho, Andreia; Miranda, Armandina; Seuanes, Filomena; Batalha Reis, AnaIntroduction: Inherited deletions removing the α-globin genes and/or their upstream regulatory elements (MCSs) give rise to alpha-thalassemia, one of the most common genetic recessive disorders worldwide. The pathology is characterized by microcytic hypochromic anemia due to reduction of the α-globin chain synthesis, which are essential for hemoglobin tetramerization. Material and Methods: In order to clarify t...
Unusual molecular mechanisms in the origin of alpha-thalassemia
Ferrão, José; Silva, Marisa; Gonçalves, Lúcia; Gomes, Susana; Loureiro, Pedro; Coelho, Andreia; Miranda, Armandina; Seuanes, Filomena; Batalha Reis, AnaHemoglobin (Hb) is a protein responsible for oxygen transportation from lungs to the entire body. It is composed by four globular subunits - the globins - each with a central core containing a heme molecule. Globins are encoded by the α- and β-globin gene clusters located at 16p13.3 and 11p15.5, respectively. The pattern of globin gene expression during development is precisely controlled by the interaction of ...
Widening the spectrum of deletions and molecular mechanisms underlying alpha-th...
Ferrão, José; Silva, Marisa; Gonçalves, Lúcia; Gomes, Susana; Loureiro, Pedro; Coelho, Andreia; Miranda, Armandina; Seuanes, Filomena; Reis, Ana BatalhaInherited deletions of α-globin genes and/or their upstream regulatory elements (MCSs) give rise to α-thalassemia, an autosomal recessive microcytic hypochromic anemia. In this study, multiplex ligation-dependent probe amplification performed with commercial and synthetic engineered probes, Gap-PCR, and DNA sequencing were used to characterize lesions in the sub-telomeric region of the short arm of chromosome 1...
Novel deletions and unusual genetic mechanisms underlying alpha-thalassemia
Ferrão, José; Silva, Marisa; Gonçalves, Lúcia; Gomes, Susana; Coelho, Andreia; Miranda, Armandina; Seuanes, Filomena; Batalha-Reis, AnaHemoglobin (Hb) is a protein responsible for oxygen transportation from lungs to the entire body. It is composed by four globular subunits - the globins - each with a central core containing a heme molecule. Globins are encoded by the α- and β-globin gene clusters located at 16p13.3 and 11p15.5, respectively. The pattern of globin genes expression during development is precisely controlled by the interaction of...
Púrpura Trombocitopénica Imune na Criança Casuística do Serviço de Hematologia ...
Pina, Francisca; Lobo, Isabel; Pinho, M. J.; Benedito, Manuela; Maricato, M. L.; Tamagnini, G.autores apresentam uma revisão de 196 casos clínicos de crianças a quem foi diagnosticada Púrpura Trombocitopénica Imune (PTI) no períodocompreendido antre 1977 e 1993, e seguidas na consulta externa de Hematologia do Hospital Pediátrico. Questionam, dado o carácter benigno da doença, a obrigatoriedade da execução de medulograma e a necessidade de tratamento. Concluem que o grupo etário mais afectado foi o das ...