15 documents found, page 1 of 2
Hierarchical HRP-crosslinked silk fibroin/ZnSr-doped TCP nancocomposites toward...
Ribeiro, V. P.; Pina, S.; Canadas, R. F.; Gheduzzi, S.; Araujo, A.; da Silva Morais, Alain; Vilela, C.; Vieira, S.; Cengiz, I. F.; Reis, R. L.[Excerpt] Introduction. Recent investigations highlight promising regenerative strategies for osteochondral (OC) tissue treatment, such as hierarchical nanocomposite scaffolds containing ionic dopants.1,2 They allow cell infiltration and ECM formation throughout the engineered cartilage and subchondral tissues. The biomechanical behavior, antibacterial properties, and in vivo performance of hierarchical nanostr...
Tissue engineering scaffolds: Future perspectives
Pina, S.; Ribeiro, V. P.; Paiva, O. C.; Correlo, V. M.; Oliveira, Joaquim M.; Reis, R. L.Tissue engineering (TE) and regenerative medicine combines the principles of biomaterials and cell transplantation to develop new tissues and to promote endogenous regeneration. The 3D scaffolds and matrices appeared as assertive approaches to guide the development of functional engineered tissues. Moreover, these structures, alone or in combination with cells and bioactive agents, bring the mechanical support ...
Collagen-based bioinks for hard tissue engineering applications: a comprehensiv...
Marques, C. F.; Diogo, G. S.; Pina, S.; Oliveira, Joaquim M.; Silva, T. H.; Reis, R. L.In the last few years, additive manufacturing (AM) has been gaining great interest in the fabrication of complex structures for soft-to-hard tissues regeneration, with tailored porosity, and boosted structural, mechanical, and biological properties. 3D printing is one of the most known AM techniques in the field of biofabrication of tissues and organs. This technique opened up opportunities over the conventiona...
Rapidly responsive silk fibroin hydrogels as an artificial matrix for the progr...
Ribeiro, V. P.; Silva-Correia, J.; Gonçalves, C.; Pina, S.; Radhouani, Hajer; Montonen, Toni; Hyttinen, J.; Roy, A.; Oliveira, A. L.; Reis, R. L.Timely and spatially-regulated injectable hydrogels, able to suppress growing tumors in response to conformational transitions of proteins, are of great interest in cancer research and treatment. Herein, we report rapidly responsive silk fibroin (SF) hydrogels formed by a horseradish peroxidase (HRP) crosslinking reaction at physiological conditions, and demonstrate their use as an artificial biomimetic three-d...
Ser ou não ser praxado? A teoria da ação planeada como modelo para compreender ...
Correia, I.; Alves, D.; Jarego, M.; Lopes, K.; Rodrigues, D.; Abrantes, L.; Boloca, A.; Carvalho, B.; Diogo, M.; Grosso, C.; Massa, M. F.; Mateus, R.Com este estudo pretendemos investigar quais são os preditores da intenção de participação dos caloiros na praxe académica. Para tal, recorremos à teoria da ação planeada (Ajzen, 1991) que permite analisar o peso relativo das atitudes, da norma subjetiva, e do controlo comportamental percebido nas intenções de ser praxado. Os participantes, estudantes universitários (N = 353) a frequentar o 1º ano de uma Licenc...
Biofunctional ionic-doped calcium phosphates: silk fibroin composites for bone ...
Pina, S.; Canadas, R. F.; Jiménez, G.; Perán, M.; Marchal, J. A.; Reis, R. L.; Oliveira, J. M.The treatment and regeneration of bone defects caused by traumatism or diseases have not been completely answered by current therapies. Lately, advanced tools and technologies have been successfully developed for bone tissue regeneration. Functional scaffolding materials such as biopolymers and bioresorbable fillers have gained particular attention, owing to their ability to promote cell adhesion, proliferation...
Cartilage and bone regeneration: how close are we to bedside?
Canadas, Raphael Faustino; Pina, S.; Marques, A. P.; Oliveira, Joaquim M.; Reis, R. L.The treatment/regeneration of bone and cartilage diseases or defects, whether induced by rheumatism, joint dysplasia, trauma, or surgery presents great challenges that have not been fully solved by the current therapies. In the last few years, tissue engineering and regenerative medicine have been proposing advanced tools and technologies for bone and cartilage tissue regeneration, and some of which have succes...
Influence of Mg-doping, calcium pyrophosphate impurities and cooling rate on th...
Torres, P. M. C.; Abrantes, J. C. C.; Kaushal, A.; Pina, S.; Doebelin, N.; Bohner, M.; Ferreira, J. M. F.Alpha and beta-tricalcium phosphates are allotropic phases which play a very important role as bone graft substitutes, namely in calcium phosphate cements. Despite extensive research efforts, contradictory reports exist on the importance of quenching for maintaining alpha-TCP purity. The role of calcium pyrophosphate impurities derived from a certain calcium-deficiency, hydroxyapatite impurities derived from ca...
Biomimetic strategies to engineer mineralised human tissues
Pina, S.; Oliveira, J. M.; Reis, R. L.In the last few years, many reports have been describing promising biocompatible and biodegradable materials that can mimic in a certain extent the multidimensional hierarchical structure of bone, while are also capable of releasing bioactive agents or drugs in a controlled manner. Despite these great advances, new developments in the design and fabrication technologies are required to address the need to engin...
Natural-based nanocomposites for bone tissue engineering and regenerative medic...
Pina, S.; Oliveira, J. M.; Reis, R. L.Tissue engineering and regenerative medicine has been providing exciting technologies for the development of functional substitutes aimed to repair and regenerate damaged tissues and organs. Inspired by the hierarchical nature of bone, nanostructured biomaterials are gaining a singular attention for tissue engineering, owing their ability to promote cell adhesion and proliferation, and hence new bone growth, co...