Encontrados 23 documentos, a visualizar página 1 de 3
3D-printed cell-instructive scaffolds based on Chondrosia reniformis collagen a...
Rocha, Miguel Soares; Marques, Ana Catarina Fernandes; Pina, Sandra Cristina Almeida; Oliveira, Joaquim M.; Reis, R. L.; Silva, Tiago H.Bone defects pose a global concern due to their high prevalence. Despite the significant advances in the development of novel therapies and sustainable biomaterial solutions, these still do not perfectly address the clinical needs, in particular, the paradigm shift of personalized treatments. In this sense, marine-origin materials allied to three-dimensional (3D) printing are arising as a feasible alternative t...
Characterization of iron oxide nanotubes obtained by anodic oxidation for biome...
Rangel, Rita de Cássia Reis; Rangel, André Luiz Reis; Silva, Kerolene Barboza da; Escada, Ana Lúcia do Amaral; Chaves, Javier Andres MunozTo improve the biocompatibility and bioactivity of biodegradable iron-based materials, nanostructured surfaces formed by metal oxides offer a promising strategy for surface functionalization. To explore this potential, iron oxide nanotubes were synthesized on pure iron (Fe) using an anodic oxidation process (50 Vâ 30 min, using an ethylene glycol solution containing 0.3% NH4F and 3% H2O, at a speed of 100 rpm)....
Anodic oxidation of 3D printed Ti6Al4V scaffold surfaces: In vitro studies
Sousa, Talita Kathleen Correia de; Maia, Fátima Raquel; Pina, Sandra Cristina Almeida; Reis, R. L.; Oliveira, Joaquim M.This study focuses on the surface modification of Ti6Al4V scaffolds produced through additive manufacturing using the Powder-Bed Fusion Electron-Beam Melting (PBF-EB) technique. From our perspective, this technique has the potential to enhance implant osseointegration, involving the growth of a layer of titanium dioxide nanotubes (TiO2) on surfaces through anodic oxidation. Scaffolds with anodized surfaces were...
Tissue-engineered approach to bone injuries
Pina, Sandra Cristina Almeida; Reis, R. L.; Oliveira, J. M.Over the past decades, great progress has been accomplished towards repairing and regenerating injured or diseased bone. Tissue-engineered scaffolding approaches have currently been acknowledged as efficient 3D biomimetic bone models, with better integration and degradation in vivo over conventional bone grafts/therapies. Those structures can be engineered with gradients of bioactive molecules and/or cells to r...
Bioinspired silk fibroin-based composite grafts as bone tunnel fillers for ante...
Ribeiro, Viviana Pinto; Costa, João B.; Carneiro, Sofia M.; Pina, Sandra Cristina Almeida; Veloso, Ana C. A.; Reis, R. L.; Oliveira, Joaquim M.Anterior cruciate ligament (ACL) replacement is still a big challenge in orthopedics due to the need to develop bioinspired implants that can mimic the complexity of bone-ligament interface. In this study, we propose biomimetic composite tubular grafts (CTGs) made of horseradish peroxidase (HRP)-cross-linked silk fibroin (SF) hydrogels containing ZnSr-doped β-tricalcium phosphate (ZnSr-β-TCP) particles, as prom...
Osteogenic lithium-doped brushite cements for bone regeneration
Hurle, K.; Maia, F. Raquel; Ribeiro, Viviana Pinto; Pina, Sandra Cristina Almeida; Oliveira, J. M.; Goetz-Neunhoeffer, F.; Reis, R. L.This study investigated the osteogenic performance of new brushite cements obtained from Li+-doped beta-tricalcium phosphate as a promising strategy for bone regeneration. Lithium (Li+) is a promising trace element to encourage the migration and proliferation of adipose-derived stem cells (hASCs) and the osteogenic differentiation-related gene expression, essential for osteogenesis. In-situ X-ray diffraction (X...
Scaffold fabrication technologies and structure/function properties in bone tis...
Collins, Maurice N.; Ren, Guang; Young, Kieran; Pina, Sandra Cristina Almeida; Reis, R. L.; Oliveira, J. M.Bone tissue engineering (BTE) is a rapidly growing field aiming to create a biofunctional tissue that can integrate and degrade in vivo to treat diseased or damaged tissue. It has become evident that scaffold fabrication techniques are very important in dictating the final structural, mechanical properties, and biological response of the implanted biomaterials. A comprehensive review of the current accomplishme...
Ion-doped brushite cements for bone regeneration
Hurle, K.; Oliveira, J. M.; Reis, R. L.; Pina, Sandra Cristina Almeida; Goetz-Neunhoeffer, F.Decades of research in orthopaedics has culminated in the quest for formidable yet resorbable biomaterials using bioactive materials. Brushite cements most salient features embrace high biocompatibility, bioresorbability, osteoconductivity, self-setting characteristics, handling, and injectability properties. Such type of materials is also effectively applied as drug delivery systems. However, brushite cements ...
Porous aligned ZnSr-doped β-TCP/silk fibroin scaffolds using ice-templating met...
Bicho, D.; Canadas, R. F.; Gonçalves, C.; Pina, Sandra Cristina Almeida; Reis, R. L.; Oliveira, J. M.The bone is a complex and dynamic structure subjected to constant stress and remodeling. Due to the worldwide incidence of bone disorders, engineered bone tissues have emerged as solution for bone grafting, which require sophisticated scaffolding architectures while keeping high mechanical performance. However, the conjugation of bone-like scaffold architecture with efficient mechanical properties is still a cr...
Horseradish peroxidase-crosslinked calcium-containing silk fibroin hydrogels as...
Pierantoni, Lara; Ribeiro, Viviana Pinto; Costa, Lígia Francisca Rodrigues; Pina, Sandra Cristina Almeida; da Silva Morais, Alain; Silva-Correia, JoanaHydrogels, being capable of mimicking the extracellular matrix composition of tissues, are greatly used as artificial matrices in tissue engineering applications. In this study, the generation of horseradish peroxidase (HRP)-crosslinked silk fibroin (SF) hydrogels, using calcium peroxide as oxidizer is reported. The proposed fast forming calcium-containing SF hydrogels spontaneously undergo SF conformational ch...