3 documents found, page 1 of 1
Increasing prevalence of HIV-1 transmitted drug resistance in Portugal
Pingarilho, Marta; Pimentel, Victor; Diogo, Isabel; Fernandes, Sandra; Miranda, Mafalda; Pineda-Peña, AC; Libin, Pieter; Theys, Kristof; Martins, MRIntroduction: Treatment for All recommendations have allowed access to antiretroviral (ARV) treatment for an increasing number of patients. This minimizes the transmission of infection but can potentiate the risk of transmitted (TDR) and acquired drug resistance (ADR). Objective: To study the trends of TDR and ADR in patients followed up in Portuguese hospitals between 2001 and 2017. Methods: In total, 11,911 p...
Drivers of HIV-1 transmission
Pineda-Peña, AC; Pingarilho, Marta; Li, Guangdi; Vrancken, Bram; Libin, Pieter; Gomes, Perpétua; Camacho, Ricardo Jorge; Theys, Kristof; Abecasis, ABBACKGROUND: Portugal has one of the most severe HIV-1 epidemics in Western Europe. Two subtypes circulate in parallel since the beginning of the epidemic. Comparing their transmission patterns and its association with transmitted drug resistance (TDR) is important to pinpoint transmission hotspots and to develop evidence-based treatment guidelines. METHODS: Demographic, clinical and genomic data were collected ...
CRF19_cpx is an evolutionary fit HIV-1 variant exclusively associated with rapi...
Kourí, Vivian; Khouri, Ricardo; Alemán, Yoan; Vercauteren, Jurgen; Pineda-Peña, AC; Theys, Kristof; Megens, S.; Moutschen, M.; Pfeifer, NicoBACKGROUND: Clinicians reported an increasing trend of rapid progression (RP) (AIDS within 3 years of infection) in Cuba. METHODS: Recently infected patients were prospectively sampled, 52 RP at AIDS diagnosis (AIDS-RP) and 21 without AIDS in the same time frame (non-AIDS). 22 patients were sampled at AIDS diagnosis (chronic-AIDS) retrospectively assessed as > 3 years infected. Clinical, demographic, virologica...