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Canine cutaneous histiocytoma: A model for human pediatric disease?

Moura, C; Sebastino, K; Pinello, K; Niza-Ribeiro, J; Santos, J; Catarino, J; Faísca, P; Amaral, AJ

This study investigates alterations at the level of the genome and at level of gene expression in dogs with Canine Cutaneous Histiocytoma (CCH). CCH is a benign tumor originating from Langerhans cells (LC), remarkably like pediatric LC Histiocytoma. While CCH is highly prevalent in young dogs, it spontaneously regresses within 2–3 mo, providing a unique opportunity to study immune-mediated tumor control. Unlike...


Exploring risk factors linked to canine lymphoma: a case-control study

Pinello, K; Leite-Martins, L; Gregório, H; Oliveira, F; Kimura, KC; Dagli, MLZ; de Matos, A; Niza-Ribeiro, J

Environmental factors, largely influenced by human behavior, account for approximately 80 % of malignant tumors. Risk factors associated with non-Hodgkin's lymphoma (NHL) have been identified in various countries among both humans and domestic animals. This study aimed to investigate potential risk factors for NHL in dogs residing in the district of Porto, Portugal. A comprehensive survey comprising 70 question...


Exploring canine mast cell tumors: An investigation into demographic characteri...

Catarino, J; Pinello, K; Niza-Ribeiro, J; Santos, J; Payan-Carreira, R; Reis, J; Faísca, P

Mast cell tumors (MCT) are among the most common neoplasia in dogs, representing up to 21 % of skin tumors. However, etiology and risk factors for its development remain unclear. This study aimed to reduce this knowledge gap by comprehensively analyzing 905 MCT cases diagnosed in Portugal between 2019 and 2021, using descriptive and inferential analyses. Most tumors affected the skin, with 69.9 % and 21.2 % cla...


Investigating the Life Expectancy at Birth of Companion Dogs in Portugal Using ...

Geraz, H; Pinello, K; Mendonça, D; Severo, M; Niza-Ribeiro, J

This study aimed to provide a comprehensive picture of the life expectancy of dogs in Portugal, focusing on the impact of diverse factors including breed, sex, size, and skull shape. The final dataset, gathering data from the national registry database, consisted of 278,116 dogs with confirmed deaths. The mean lifespan at birth for all the dogs was around 8.91 years, with the female dogs tended to have a simila...


Comparative epidemiological study of breast cancer in humans and canine mammary...

Carvalho, PT; Niza-Ribeiro, J; Amorim, I; Queiroga, F; Severo, M; Ribeiro, AI; Pinello, K

Dogs spontaneously develop mammary gland tumors (MGT) and exhibit striking similarities in clinical and epidemiological characteristics to human breast cancer (HBC). Descriptive and comparative analysis of HBC and canine MGT with a focus on evaluating similarities and geographical distribution were the aims of this study. HBC cases were obtained from North Regional Oncological Registry (RORENO) (2010–2015) and ...


Vet-OncoNet: Developing a Network of Veterinary Oncology and Reporting a Pionee...

Pinello, K; Pires, I; Castro, AF; Carvalho, PT; Santos, A; de Matos, A; Queiroga, F; Niza Ribeiro, J

Vet-OncoNet is a replicable tripartite animal cancer database with the scientific and academic purposes of collecting data and producing evidence-based knowledge for cancer science in general. Inspired by the One Health vision, Vet-OncoNet uses business intelligence tools to optimize the process of capturing, treating, and reporting animal cancer data to a national level in three interfaces: ACR (animal cancer ...


Cross Species Analysis and Comparison of Tumors in Dogs and Cats, by Age, Sex, ...

Pinello, K; Pires, I; Castro, AF; Carvalho, PT; Santos, A; de Matos, A; Queiroga, F; Canadas-Sousa, A; Dias-Pereira, P; Catarino, J; Faísca, P

The animal cancer burden is essential for the translational value of companion animals in comparative oncology. The present work aims to describe, analyze, and compare frequencies and associations of tumors in dogs and cats based on the Animal Cancer Registry created by Vet-OncoNet. With 9079 registries, regarding 2019 and 2020, 81% (n = 7355) belonged to dogs. In comparison, cats have a general one-year right ...


Vet-ICD-O-Canine-1, a System for Coding Canine Neoplasms Based on the Human ICD...

Pinello, K; Baldassarre, V; Steiger, K; Paciello, O; Pires, I; Laufer Amorim, R; Oevermann, A; Niza Ribeiro, J; Aresu, L; Rous, B; Znaor, A; Cree, IA

Cancer registries are fundamental tools for collecting epidemiological cancer data and developing cancer prevention and control strategies. While cancer registration is common in the human medical field, many attempts to develop animal cancer registries have been launched over time, but most have been discontinued. A pivotal aspect of cancer registration is the availability of cancer coding systems, as provided...


Vet-OncoNet: Malignancy Analysis of Neoplasms in Dogs and Cats

Pinello, K; Amorim, I; Pires, I; Canadas Sousa, A; Catarino, J; Faisca, P; Branco, S; Peleteiro, MC; Silva, D; Severo, M; Niza Ribeiro, J

Analysis of canine and feline tumor malignancy data can help clinicians identify high-risk patients and make more accurate decisions. Based on a sample of 16,272 cancer records, including 3266 cats and 13,006 dogs, collected from January 2019 to December 2021 in the Vet-OncoNet Network database, this study aimed to compare the tumor malignancy profile between cats and dogs, considering animal-related factors (s...


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