24 documents found, page 1 of 3
Hazard Assessment of Benchmark Metal-Based Nanomaterials Through a Set of In Vi...
Vital, Nádia; Pinhão, Mariana; Yamani, Naouale El; Rundén-Pran, Elise; Louro, Henriqueta; Dušinská, Maria; Silva, Maria JoãoFor safety assessment of nanomaterials (NMs), in vitro genotoxicity data based on welldesigned experiments is required. Metal-based NMs are amongst the most used in consumer products. In this chapter, we report results for three metal-based NMs, titanium dioxide (NM- 100), cerium dioxide (NM-212) and silver (NM-302) in V79 cells, using a set of in vitro genotoxicity assays covering different endpoints: the medi...
Combined cytotoxic and genotoxic effects of ochratoxin A and fumonisin B1 in hu...
Pinhão, Mariana; Tavares, Ana Maria; Loureiro, Susana; Louro, Henriqueta; Alvito, Paula; Silva, Maria JoãoFood products can be contaminated by several fungi species and each species may produce different mycotoxins, leading to human combined exposure. Although predictions about the joint toxic effects of mycotoxins can be made from their individual toxicities, experimental data is still limited to allow a reliable hazard assessment. Thus, this study aimed to characterize the combined cytotoxic and genotoxic effects...
Biological impact of metal nanomaterials in relation to their physicochemical c...
Louro, Henriqueta; Saruga, Andreia; Santos, Joana; Pinhão, Mariana; Silva, Maria JoaoSeveral metal and metal oxide nanomaterials (NMs), e.g., cerium dioxide NMs(CeO2), barium sulphate NMs(BaSO4) and titanium dioxide NMs(TiO2), display advantageous properties over the bulk materials and have a broad range of innovative applications in food, industry and consumer products. Whether these materials are hazardous and impact on human health or the environment remains an issue that needs to be address...
A multi-endpoint approach to the combined toxic effects of patulin and ochratox...
Assunção, Ricardo; Pinhão, Mariana; Loureiro, Susana; Alvito, Paula; Silva, Maria JoãoHumans can be exposed to a complex and variable combination of mycotoxins. After ingestion, intestinal mucosa constitutes the first biological barrier that can be exposed to high concentrations of these toxins. The present study aimed to characterize the combined cytotoxicity, genotoxicity and impact on the gastrointestinal barrier integrity of patulin (PAT, 0.7 μM to 100 μM) and ochratoxin A (OTA, 1 μM to 200 ...
A multi-endpoint approach to the combined toxic effects of patulin and ochratox...
Assunção, Ricardo; Pinhão, Mariana; Loureiro, Susana; Alvito, Paula; Silva, Maria JoãoHumans can be exposed to a complex and variable combination of mycotoxins. After ingestion, intestinal mucosa constitutes the first biological barrier that can be exposed to high concentrations of these toxins. The present study aimed to characterize the combined cytotoxicity, genotoxicity and impact on the gastrointestinal barrier integrity of patulin (PAT, 0.7 μM to 100 μM) and ochratoxin A (OTA, 1 μM to 200 ...
Contribution to the hazard assessment of benchmark metallic nanomaterials throu...
Vital, Nádia; El Yamani, Naouale; Pinhão, Mariana; Rúden-Pra, Elise; Louro, Henriqueta; Dušinská, Maria; Silva, Maria JoãoMetallic nanomaterials are among the most commonly applied manufactured nanomaterials (NM). Regardless of the considerable efforts to assess their safety, the presently available data do not allow for general and consistent conclusions. Moreover, the validity of the classical in vitro testing systems for NMs hazard assessment has been questioned and needs confirmation. In the present study, the toxicity of thre...
Contribution to the hazard assessment of benchmark metallic nanomaterials throu...
Vital, Nádia; El Yamani, Naouale; Pinhão, Mariana; Rúden-Pra, Elise; Louro, Henriqueta; Dušinská, Maria; Silva, Maria JoãoBackground and Aim: Metall-based nanomaterials (NMs) are among the most commonly applied manufactured nanomaterials (NM). Regardless of the considerable efforts to assess their safety, the presently available data do not allow for general and consistent conclusions. Moreover, the validity of the classical in vitro testing systems for NMs hazard assessment has been questioned and needs confirmation. The present ...
Mixtures health effects: mycotoxins in food
Pinhão, Mariana; Loureiro, Susana; Louro, Henriqueta; Alvito, Paula; Silva, Maria JoãoIn recent years, the risk assessment paradigm has shifted from the single-exposure and single-chemical adverse effect scenario to the one of multiple exposures and combined adverse effects. The present work describes the in vitro combined toxicity of mycotoxins at the renal level, as a case study. Mycotoxins are often present in food and feed, as secondary metabolites of contaminating fungi and human co-exposur...
Nanotoxicology and nanotechnology interplay towards a safe and responsible inno...
Silva, Maria João; Ventura, Célia; Dias, Kamila; Saruga, Andreia; Pinhão, Mariana; Louro, HenriquetaThe European Union Strategic and Action Plan for Nanosciences and Nanotechnologies emphasizes the need of ensuring the development of safe, integrated, and responsible nanotechnologies and nanotechnology products. Indeed, although the use of manufactured nanomaterials (NM) is widespread and has been considered greatly beneficial for several scientific and technological areas, uncertainties about their safety st...
Evaluation of chemopreventive effects of a hexanic extract prepared from Morind...
Torrejais, Joana; Pinhão, Mariana; Guidoti, David Teixeira; Silva, Maria JoãoThe identification of bioactive natural compounds that are able to reduce the deleterious health effects of toxicants is of utmost importance. One of these toxicants is patulin (PAT), a common mycotoxin affecting fruits’ integrity and representing a serious health concern. Morinda citrifolia (noni) is a tropical plant that has been used in traditional medicine mainly for its therapeutic properties. This work in...