3 documents found, page 1 of 1
Neurodegeneration in systemic lupus erythematosus
Dias-Santos, Arnaldo; Tavares Ferreira, Joana; Pinheiro, Sofia; Cunha, João Paulo; Alves, Marta; Papoila, A.L.; Moraes-Fontes, Maria FranciscaBackground: Systemic lupus erythematosus (SLE) is a chronic, autoimmune and multisystemic disease. Recent studies with functional and structural magnetic resonance imaging and cognitive tests report an unexpectedly high frequency of central nervous system involvement, even in patients with asymptomatic SLE. The purpose of this study was to identify early signs of retinal neurodegeneration by comparing the thick...
Characterization of a large cluster of HIV-1 A1 infections detected in Portugal...
Araújo, Pedro M.M.; Carvalho, Alexandre; Pingarilho, Marta; Faria, Domitília; Pinho, Raquel; Ferreira, José; Proença, Paula; Nunes, SofiaHIV-1 subtypes associate with differences in transmission and disease progression. Thus, the existence of geographic hotspots of subtype diversity deepens the complexity of HIV-1/AIDS control. The already high subtype diversity in Portugal seems to be increasing due to infections with sub-subtype A1 virus. We performed phylogenetic analysis of 65 A1 sequences newly obtained from 14 Portuguese hospitals and 425 ...
Choroidal thickness changes in systemic lupus erythematosus patients
Dias-Santos, Arnaldo; Tavares Ferreira, Joana; Pinheiro, Sofia; Paulo Cunha, João; Alves, Marta; Papoila, A.L.; Moraes-Fontes, Maria FranciscaPurpose: To compare choroidal thickness (CT) between patients with systemic lupus erythematosus (SLE) without ophthalmologic manifestations and a control group. To study the effects in CT of disease duration, activity index, medication and systemic comorbidities. Methods: Cross-sectional study where spectral-domain optical coherence tomography with enhanced depth imaging was used to measure CT in 13 locations, ...