14 documents found, page 1 of 2
Studying the neuroprotective role of bone marrow-derived mesenchymal stem cell ...
Pinheiro, Bárbara Filipa MendesA doença de Parkinson (DP) é a doença motora mais comum, afetando cerca de 6.1 milhões de pessoas mundialmente. Sintomas motores como bradicinesia, tremor em repouso e rigidez muscular são as principais características clínicas da DP. No entanto, sintomas não motores são também determinantes na qualidade de vida e da incapacidade geral do doente. Perda neuronal na substância nigra pars compacta (SNpc) que causa...
Preclinical assessment of mesenchymal-stem-cell-based therapies in spinocerebel...
Correia, Joana Sofia Silva; Carvalho, Andreia Alexandra Neves; Pinheiro, Bárbara Filipa Mendes; Pires, Joel Pereira; Teixeira, Fábio Gabriel RodriguesThe low regeneration potential of the central nervous system (CNS) represents a challenge for the development of new therapeutic strategies for neurodegenerative diseases, including spinocerebellar ataxias. Spinocerebellar ataxia type 3 (SCA3)—or Machado–Joseph disease (MJD)—is the most common dominant ataxia, being mainly characterized by motor deficits; however, SCA3/MJD has a complex and heterogeneous pathop...
Unilateral intrastriatal 6-hydroxydopamine lesion in mice: a closer look into n...
Pinheiro, Bárbara Filipa Mendes; Cunha, Carina Isabel Soares; Marote, Ana Maria Franco Aveiro; Loureiro-Campos, Eduardo; Campos, Jonas OliveiraParkinson’s disease (PD) is a prevalent movement disorder characterized by the progressive loss of dopaminergic neurons in substantia nigra pars compacta (SNpc). The 6-hydroxydopamine (6-OHDA) lesion is still one of the most widely used techniques for modeling Parkinson’s disease (PD) in rodents. Despite commonly used in rats, it can be challenging to reproduce a similar lesion in mice. Moreover, there is a lac...
Constitutive deficiency of the neurogenic hippocampal modulator AP2γ promotes a...
Loureiro-Campos, Eduardo; Mateus-Pinheiro, António; Patrício, Patrícia; Cunha, Carina Isabel Soares; Silva, Joana; Sardinha, Vanessa Alexandra MoraisThe transcription factor activating protein two gamma (AP2γ) is an important regulator of neurogenesis both during embryonic development as well as in the postnatal brain, but its role for neurophysiology and behavior at distinct postnatal periods is still unclear. In this work, we explored the neurogenic, behavioral, and functional impact of a constitutive and heterozygous AP2γ deletion in mice from early post...
Bone marrow mesenchymal stem cells' secretome exerts neuroprotective effects in...
Pinheiro, Bárbara Filipa Mendes; Anjo, Sandra I.; Manadas, Bruno; da Silva, Jorge D.; Marote, Ana Maria Franco Aveiro; Behie, Leo A.; Teixeira, Fábio G.Parkinson's disease (PD) is characterized by a selective loss of dopamine (DA) neurons in the human midbrain causing motor dysfunctions. The exact mechanism behind dopaminergic cell death is still not completely understood and, so far, no cure or neuroprotective treatment for PD is available. Recent studies have brought attention to the variety of bioactive molecules produced by mesenchymal stem cells (MSCs), g...
Exploiting the impact of the secretome of MSCs isolated from different tissue s...
Silva, Rita Catarina Assunção Ribeiro; Pinheiro, Bárbara Filipa Mendes; Patrício, Patrícia; Behie, Leo A.; Teixeira, Fábio Gabriel RodriguesCell transplantation using Mesenchymal stem cell (MSC) secretome have recently been presented as a possible free-based therapy for CNS related disorders. MSC secretome is rich in several bio-factors that act synergically towards the repair of damaged tissues, thus making it an ideal candidate for regenerative applications. Great effort is currently being made to map the molecules that compose the MSC secretome....
Secretome of Undifferentiated Neural Progenitor Cells Induces Histological and ...
Pinheiro, Bárbara Filipa Mendes; Teixeira, Fábio Gabriel Rodrigues; Anjo, Sandra I.; Manadas, Bruno; Behie, Leo A.; Salgado, A. J.Parkinson's disease (PD) is a progressive neurodegenerative movement disorder that results from the death of dopamine (DA) neurons. Over recent years, differentiated or undifferentiated neural stem cells (NSCs) transplantation has been widely used as a means of cell replacement therapy. However, compelling evidence has brought attention to the array of bioactive molecules produced by stem cells, defined as secr...
Cell secretome based approaches in Parkinson's disease regenerative medicine
Marques, Cláudia R.; Marote, Ana Maria Franco Aveiro; Pinheiro, Bárbara Filipa Mendes; Teixeira, Fábio Gabriel Rodrigues; Salgado, A. J.The available therapeutic strategies for Parkinson's disease (PD) rely only on the amelioration of the symptomatology of the disease, lacking neuroprotection or neuroregeneration capacities. Therefore, the development of disease modifying strategies is extremely important for the management of PD in the long term. Areas covered: In this review, the authors provide an overview of the current therapeutic approach...
Old and new challenges in Parkinson's disease therapeutics
Pires, Ana O.; Teixeira, Fábio Gabriel Rodrigues; Pinheiro, Bárbara Filipa Mendes; Serra, Sofia Cravino; Sousa, Nuno; Salgado, A. J.Parkinson's disease (PD) is a neurodegenerative disorder characterized by the degeneration of dopaminergic neurons and/or loss od neuronal projections, in several dopaminergic networks. Current treatments for idiopathic PD rely mainly on the use of pharmacologic agents to improve motor symptomatology of PD patients. Nevertheless, so far PD remains an incurable disease. Therefore, it is of utmost importance to e...
Impact of the Secretome of Human Mesenchymal Stem Cells on Brain Structure and ...
Teixeira, Fábio Gabriel Rodrigues; Carvalho, Miguel M.; Panchalingam, K. M.; Rodrigues, Ana João; Pinheiro, Bárbara Filipa Mendes; Anjo, SandraResearch in the last decade strongly suggests that mesenchymal stem cell (MSC)-mediated therapeutic benefits are mainly due to their secretome, which has been proposed as a possible therapeutic tool for the treatment of Parkinson's disease (PD). Indeed, it has been shown that the MSC secretome increases neurogenesis and cell survival, and has numerous neuroprotective actions under different conditions. Addition...