10 documents found, page 1 of 1
Genetic and microenvironmental intra-tumor heterogeneity impacts colorectal can...
Sobral, Daniel; Martins, Marta; Kaplan, Shannon; Golkaram, Mahdi; Salmans, Michael; Khan, Nafeesa; Vijayaraghavan, Raakhee; Casimiro, SandraColorectal cancer (CRC) is a highly diverse disease, where different genomic instability pathways shape genetic clonal diversity and tumor microenvironment. Although intra-tumor heterogeneity has been characterized in primary tumors, its origin and consequences in CRC outcome is not fully understood. Therefore, we assessed intra- and inter-tumor heterogeneity of a prospective cohort of 136 CRC samples. We demon...
O lugar das artes plásticas nas ações dos educadores de infância
Costa, Ana LúciaSabendo que a arte deveria estar sempre interligada com as restantes atividades, torna-se fundamental que não se dissocie a arte da educação, no presente relatório pretende-se entender as conceções do educador e da educadora relativamente à expressão plástica, mais concretamente o uso dos objetos do quotidiano como forma de potenciar esta expressão, pois através da expressão plástica é possível a criança expres...
ÍNDICE DE RESPOSTA INFLAMATÓRIA SISTÉMICA COMO FATOR PROGNÓSTICO EM DOENTES COM...
Dâmaso, Sara; Paiva, Rita; Pinho, Inês; Martins, Miguel Esperança; Brás, Raquel Lopes; Costa, Ana Lúcia; Quintela, António; Pinto, ConceiçãoINTRODUÇÃO O adenocarcinoma do pâncreas (PDAC) apresenta-se como um tumor sólido com prognóstico extremamente desfavorável, tendo uma sobrevida global (OS) aos 5 anos de aproximadamente 5%. Na doença metastizada, os esquemas de quimioterapia (QT) aprovados em primeira linha são variados, maioritariamente à base de platino ou gemcitabina. O índice de resposta inflamatória sistémica (SIRI) consiste num scor...
HERVs establish a distinct molecular subtype in stage II/III colorectal cancer ...
Golkaram, Mahdi; Salmans, Michael L.; Kaplan, Shannon; Vijayaraghavan, Raakhee; Martins, Marta; Khan, Nafeesa; Garbutt, Cassandra; Wise, AaronColorectal cancer (CRC) is one of the most lethal malignancies. The extreme heterogeneity in survival rate is driving the need for new prognostic biomarkers. Human endogenous retroviruses (hERVs) have been suggested to influence tumor progression, oncogenesis and elicit an immune response. We examined multiple next-generation sequencing (NGS)-derived biomarkers in 114 CRC patients with paired whole-exome and wh...
Levels of circulating Fibroblast Growth Factor 23 (FGF23) and prognosis in canc...
Mansinho, André; Ferreira, Arlindo; Casimiro, Sandra; Alho, Irina; Vendrell, Ines; Costa, Ana Lúcia; Sousa, Rita; Marques, Catarina; Pulido, CatarinaThe fibroblast growth factor (FGF) signaling pathway plays a key role in tumorigenesis and is recognized as a potential therapeutic target. In this study, the authors aimed to assess the impact of serum FGF23 levels in the prognosis of patients with cancer and bone metastases from solid tumors. A cohort of 112 patients with cancer and metastatic bone disease were treated with bone-targeted agents (BTA). Serum b...
From engineering geosciences mapping towards sustainable urban planning
Chaminé, Helder I.; Teixeira, José; Freitas, Liliana; Pires, Ana; Silva, Rui S.; Pinho, Telma; Monteiro, Rosália; Costa, Ana Lúcia; Abreu, TiagoMaps are of key topical importance in urban geoscience and engineering practice, mainly in field data synthesis and communication related to a number of fields, such as geomatic techniques, applied geology and geomorphology, engineering geology, soil and rock geotechnics, slope geotechnics, subsurface site geotechnical investigations, urban hydrology, hydraulics and sanitation, coastal zones management, urban g...
Prevention of nausea and vomiting in patients undergoing oral anticancer therap...
Costa, Ana Lúcia; Marques, Catarina; Pacheco, Teresa; Macedo, Daniela; Sousa, Ana Rita; Pulido, Catarina; Quintela, António; Costa, LuisChemotherapy-induced nausea and vomiting (CINV) is still a common and debilitating side effect despite recent advances in its prevention and treatment. The intrinsic emetogenicity of chemotherapy agents allowed grouping into four risk groups (high, moderate, low, and minimal risk of emetogenicity). The prevention of acute and delayed CINV for intravenous agents and one day regimens is well studied, although, th...
The treatment of liver metastases in patients with neuroendocrine tumors in 2012
Macedo, Daniela; Amaral, Teresa; Fernandes, Isabel; Sousa, Ana Rita; Costa, Ana Lúcia; Távora, Isabel; Quintela, António; Cortes, Paulo; Costa, LuisNeuroendocrine tumors (NETs) comprise a heterogeneous group of tumors that form a distinct entity. Approximately 75-80% of patients present with liver metastases at the time of their diagnosis, and 20%-25% will develop these lesions in the course of their disease. The presence of secondary deposits in the liver significantly increases the morbidity and mortality in these patients. The only potentially curative ...
Viver o estado terminal de um familiar: leitura salutogénica de resultados de u...
Oliveira, Clara Costa; Costa, Ana LúciaO objetivo deste artigo é interpretar dados obtidos num estudo de caso de tipo fenomenológico, que pesquisou o sofrimento de dezesseis cuidadores principais (familiares) de doentes em estado terminal, hospitalizados. Os dados desse estudo são aqui interpretados à luz do pré-paradigma salutogénico de A. Antonovsky, que promove a saúde, e não a doença, cumprindo finalidades proclamadas pela OMS, nomeadamente em O...
Viver o estado terminal de um familiar: leitura salutogénica de resultados de u...
Oliveira, Clara Costa; Costa, Ana LúciaThe aim of this paper is to interpret data obtained in a phenomenological case study that researched the suffering of sixteen main caregivers (family members) of terminally ill hospitalized patients. The data of that study are interpreted here in light of A. Antonovsky's salutogenic pre-paradigm, which promotes health, not disease, fulfilling the objectives proclaimed by WHO, particularly in Ottawa. The methodo...