4 documents found, page 1 of 1
MIRRAGGE – Minimum Information Required for Reproducible AGGregation Experiments
Martins, PM; Navarro, S; Silva, A; Pinto, M; Sárkány, Z; Figueiredo, F; Pereira, PJB; Pinheiro, F; Bednarikova, Z; Burdukiewicz, M; Galzitskaya, OVReports on phase separation and amyloid formation for multiple proteins and aggregation-prone peptides are recurrently used to explore the molecular mechanisms associated with several human diseases. The information conveyed by these reports can be used directly in translational investigation, e.g., for the design of better drug screening strategies, or be compiled in databases for benchmarking novel aggregatio...
Repositioning tolcapone as a potent inhibitor of transthyretin amyloidogenesis ...
Sant'Anna, R; Gallego, P; Robinson, L; Pereira-Henriques, A; Ferreira, N; Pinheiro, F; Esperante, S; Pallares, I; Huertas, O; Almeida, M; Reixach, NTransthyretin (TTR) is a plasma homotetrameric protein implicated in fatal systemic amyloidoses. TTR tetramer dissociation precedes pathological TTR aggregation. Native state stabilizers are promising drugs to treat TTR amyloidoses. Here we repurpose tolcapone, an FDA-approved molecule for Parkinson's disease, as a potent TTR aggregation inhibitor. Tolcapone binds specifically to TTR in human plasma, stabilizes...
Gestão do risco
Alves, N; Fernandes, F; Pinheiro, F
Melanoma da Conjuntiva: Estudo Clínico e de Prognóstico numa População Portuguesa
Pinheiro, F; Proença, R