14 documents found, page 1 of 2
Advancing Access to Intestinal Microbiota Transplant: Bridging the Gap Between ...
Dinis, L; Pinheiro, H; Póvoa, P; Calhau, C; Pestana, D; Marques, CClostridioides difficile is an opportunistic pathogen that can cause a range of conditions, from asymptomatic carriage to severe illness, posing a significant public health threat due to its high mortality rates and substantial healthcare costs. Traditional treatment options, including antibiotics, often fail to eradicate the infection, leading to recurrent cases that severely impact patients' lives. Intestinal...
Fatal Case of Progressive Mpox in a Patient with AIDS—Viral Enteropathy and Mal...
Caria, J; Vara-Luiz, F; Maia, I; Joosten, A; Val-Flores, L; Pinheiro, H; Póvoas, D; Germano, N; Maltez, FWe report a fatal case of disseminated mpox infection that progressed over more than three months in an HIV-infected patient with acquired immunodeficiency syndrome (AIDS). Mucocutaneous, pleuropulmonary, central nervous system, and gastrointestinal involvement was documented. This course of disease resembles progressive vaccinia, a formerly reported disease caused by uncontrolled replication of smallpox vaccin...
Magnetic Resonance Imaging Target Fusion Biopsy vs. Transrectal Ultrasound-Guid...
Guimarães, T; Gil, M; Medeiros, M; Andrade, V; Guerra, J; Pinheiro, H; Fernandes, F; Pina, J; Lopes Dias, J; Campos Pinheiro, LObjectives: The aim of this study was to com-pare the risk of International Society of Urological Pathology (ISUP) score upgrading between magnetic resonance imaging targeted fusion biopsy (MRI-TB) and tran-srectal ultrasound-guided biopsy (TRUS-B) in the final radical prostatectomy (RP) specimen pathological report. Materials and methods: This retrospective single center study included 51 patients with prostate...
Clinical and Epidemiological Features of Hospitalized and Ambulatory Patients w...
Caria, J; Pinto, R; Leal, E; Almeida, V; Cristóvão, G; Gonçalves, AC; Torres, M; Santos, MB; Pinheiro, H; Póvoas, D; Seixas, D; Lino, S; Cardoso, OMonkeypox, a neglected and re-emergent zoonotic disease caused by monkeypox virus (MPXV) infection, has been endemic in Central and Western Africa for decades. More recently, an outbreak has spread to a global level, occurring in sites with no previous reported cases and being clustered among men who have sex with men, suggesting new modes of transmission. There is an urgent need for research for a better under...
A Case of Central Nervous System Infection by Candida Famata in an Immunosuppre...
Caria, J; Leal, E; Dias, A; Pinheiro, H; Póvoas, D; Maltez, FInvasive fungal infections caused by Candida species are increasingly observed in immunosuppressed patients. Candida albicans is the more often identified species and neurocandidiasis is associated with high mortality rates. Diagnosis and treatment of these infections are frequently challenging. We report a case of central nervous system infection caused by Candida famata in an HIV-1 infected patient. To our be...
Thromboembolic Risk in COVID-19 Patients: Is There a Hidden Link?
Cidade, J; Pinheiro, H; Dias, A; Santos, M; Nascimento, B; Figueiredo, C; Pinto, R; Pereira, L; Rodrigues, C; Maltez, FBackground Although evidence has emerged indicating that patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia present a high risk of venous thromboembolism (VTE), its real incidence and best diagnosis course remain unclear. In this study, we aimed to determine the incidence of pulmonary embolism in these patients and the role of D-dimer serum level as a predictive factor of a new...
The cdh1 c.1901c>t variant: A founder variant in the portuguese population w...
Barbosa-Matos, R; Leal Silva, R; Garrido, L; Aguiar, AC; Garcia-Pelaez, J; André, A; Seixas, S; Sousa, SP; Ferro, L; Vilarinho, L; Gullo, I; Devezas, VHereditary diffuse gastric cancer (HDGC) caused by CDH1 variants predisposes to early-onset diffuse gastric (DGC) and lobular breast cancer (LBC). In Northern Portugal, the unusually high number of HDGC cases in unrelated families carrying the c.1901C>T variant (formerly known as p.A634V) suggested this as a CDH1-founder variant. We aimed to demonstrate that c.1901C>T is a bona fide truncating variant inducing ...
Gut Microbiota Diversity and C-Reactive Protein Are Predictors of Disease Sever...
Moreira-Rosário, A; Marques, C; Pinheiro, H; Araújo, JR; Ribeiro, P; Rocha, R; Mota, I; Pestana, D; Ribeiro, R; Pereira, A; Sousa, MJ; Pereira-Leal, JThe risk factors for coronavirus disease 2019 (COVID-19) severity are still poorly understood. Considering the pivotal role of the gut microbiota on host immune and inflammatory functions, we investigated the association between changes in the gut microbiota composition and the clinical severity of COVID-19. We conducted a multicenter cross-sectional study prospectively enrolling 115 COVID-19 patients categoriz...
Daily Intake of Wheat Germ-Enriched Bread May Promote a Healthy Gut Bacterial M...
Moreira-Rosário, A; Marques, C; Pinheiro, H; Norberto, S; Sintra, D; Teixeira, JA; Calhau, C; Azevedo, LFPurpose: Wheat bran fibre has a beneficial effect on gastrointestinal function, but evidence for wheat germ is scarce. Accordingly, we evaluated the effects of daily intake of wheat germ on gastrointestinal discomfort and gut microbiota by adding wheat germ to refined (white) wheat bread, the most consumed bread type. We hypothesised that an improvement in the composition of refined bread could beneficially aff...
Does Intake of Bread Supplemented with Wheat Germ Have a Preventive Role on Car...
Moreira-Rosário, A; Pinheiro, H; Marques, C; Teixeira, JA; Calhau, C; Azevedo, LFOBJECTIVE: Intake of whole grains is associated with a reduced risk of cardiovascular disease (CVD). This evidence is also strong for bran alone, but findings about germ are conflicting. Our aim was to elucidate the role of germ in primary prevention of cardiovascular events, and therefore, a staple food was selected for 6 g of germ supplementation. This corresponds to sixfold increase in the global mean consum...