22 documents found, page 1 of 3
Incidental versus symptomatic nonfunctioning pituitary adenomas: Are they diffe...
Guerreiro, V; Mendonça, F; Ferreira, HU; Freitas, P; Pereira, J; Bernardes, I; Pinheiro, J; Guimarães, T; Carvalho, DBackground Nonfunctioning pituitary adenomas (NFPAs) constitute one of the most common tumours in the sellar region and are often discovered only when associated with compressive symptoms. With the frequent use of brain imaging, there has been an increase in the prevalence of incidentally discovered NFPAs.Aim We aim to determine the prevalence of incidental diagnosis with NPAs observed over a decade and compare...
Stabilin-1 plays a protective role against Listeria monocytogenes infection thr...
Pombinho, R; Pinheiro, J; Resende, M; Meireles, D; Jalkanen, S; Sousa, S; Cabanes, DScavenger receptors are part of a complex surveillance system expressed by host cells to efficiently orchestrate innate immune response against bacterial infections. Stabilin-1 (STAB-1) is a scavenger receptor involved in cell trafficking, inflammation, and cancer; however, its role in infection remains to be elucidated. Listeria monocytogenes (Lm) is a major intracellular human food-borne pathogen causing seve...
REALMS Study: Real-World Effectiveness and Safety of Fingolimod in Patients wit...
Batista, S; Nunes, CC; Cerqueira, JJ; Martins Silva, A; Correia de Sá, J; Ferreira, J; Mendonça, MT; Pinheiro, J; Salgado, V; Correia, AS; Sequeira, JBackground: Fingolimod, an oral sphingosine 1-phosphate receptor modulator, is approved by EMA for relapsing-remitting multiple sclerosis (RRMS). Objectives: To assess the effectiveness and safety of fingolimod in patients with RRMS in real-world clinical practice in Portugal. Methods: Retrospective, multicentre, non-interventional study, reporting 3 years follow-up of data collected from October 2015 to July 2...
REALMS study: real-world effectiveness and safety of fingolimod in patients wit...
Batista, S; Nunes, C; Cerqueira, J; Silva, A; Sá, J; Ferreira, J; Mendonça, M; Pinheiro, J; Salgado, V, et al.Background: Fingolimod, an oral sphingosine 1-phosphate receptor modulator, is approved by EMA for relapsing-remitting multiple sclerosis (RRMS). Objectives: To assess the effectiveness and safety of fingolimod in patients with RRMS in real-world clinical practice in Portugal. Methods: Retrospective, multicentre, non-interventional study, reporting 3 years follow-up of data collected from October 2015 to July 2...
Listeria monocytogenes interferes with host cell mitosis through its virulence ...
Costa, AC; Pinheiro, J; Reis, SA; Cabanes, D; Sousa, SListeria monocytogenes is among the best-characterized intracellular pathogens. Its virulence factors, and thewaythey interfere with host cells to hijack host functions and promote the establishment and dissemination of the infection, have been the focus of multiple studies over the last 30 years. During cellular infection, L. monocytogenes was shown to induce host DNA damage and delay the host cell cycle to it...
The epidemiology of multiple sclerosis in the entre Douro e Vouga region of nor...
Branco, M; Alves, I; Martins, de Silva, A; Pinheiro, J; Sá, MJ; Correia, I; Sousa, L; Brandão, E; Veira, C; Gomes, B; Ruano, LBackground. The prevalence of Multiple Sclerosis (MS) has been increasing worldwide and the north–south gradient of prevalence may be disappearing in the Northern hemisphere. The few previous prevalence studies performed in Portugal have reported a lower prevalence than the average for Western Europe. The aim of this study is to estimate the prevalence of MS in the Entre Douro e Vouga region, in Northern Portug...
Iatrogenia num Caso de 6º Impactados nos 5ª Decíduos
Pereira, A; Martins, J; Pinheiro, J; Prates, M; Mussá, Y
Consensus Recommendations of the Multiple Sclerosis Study Group and Portuguese ...
Abreu, P; Pedrosa, R; Sá, MJ; Cerqueira, J; Sousa, L; Da Silva, AM; Pinheiro, J; De Sá, J; Batista, S; Simões, RM; Pereira, DJ; Vilela, P; Vale, JINTRODUCTION: Magnetic resonance imaging is established as a recognizable tool in the diagnosis and monitoring of multiple sclerosis patients. In the present, among multiple sclerosis centers, there are different magnetic resonance imaging sequences and protocols used to study multiple sclerosis that may hamper the optimal use of magnetic resonance imaging in multiple sclerosis. In this context, the Group of St...
Consensus Recommendations of the Multiple Sclerosis Study Group and Portuguese ...
Abreu, P; Pedrosa, R; Sá, MJ; Cerqueira, J; Sousa, L; Da Silva, AM; Pinheiro, J; De Sá, J; Batista, S; Simões, RM; Pereira, DJ; Vilela, P; Vale, JINTRODUCTION: Magnetic resonance imaging is established as a recognizable tool in the diagnosis and monitoring of multiple sclerosis patients. In the present, among multiple sclerosis centers, there are different magnetic resonance imaging sequences and protocols used to study multiple sclerosis that may hamper the optimal use of magnetic resonance imaging in multiple sclerosis. In this context, the Group of St...
MouR controls the expression of the Listeria monocytogenes Agr system and media...
Pinheiro, J; Lisboa, J; Pombinho, R; Carvalho, F; Carreaux, A; Brito, C; Pöntinen, A; Korkeala, H; Santos, NM; Morais-Cabral, JH; Sousa, S; Cabanes, DThe foodborne pathogen Listeria monocytogenes (Lm) causes invasive infection in susceptible animals and humans. To survive and proliferate within hosts, this facultative intracellular pathogen tightly coordinates the expression of a complex regulatory network that controls the expression of virulence factors. Here, we identified and characterized MouR, a novel virulence regulator of Lm. Through RNA-seq transcri...